Rates and Mechanisms of Bacterial Mutagenesis from Maximum-Depth Sequencing

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Jee, Justin; Rasouly, Aviram; Shamovsky, Ilya; Akivis, Yonatan; Steinman, Susan; Mishra, Bud; Nudler, Evgeny;

In 1943, Luria and Delbrück used a phage resistance assay to establish spontaneous mutation as a driving force of microbial diversity1. Mutation rates are still studied using such assays, but these can only examine the small minority of mutations conferring survival in ... View more
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