publication . Other literature type . 1982

Specific effects on human neutrophils of antibodies to a membrane protein constituent of neutrophil receptors for chemotactic formyl-methionyl peptides

Goetzl, E. J.; Foster, D. W.; Goldman, D. W.;
Open Access English
  • Published: 01 Feb 1982
Abstract
IgG and Fab were prepared from goat antisera to MP-2, the quantitatively predominant membrane protein constituent of human neutrophil receptors for chemotactic formyl-methionyl peptides. Only 10%–25% of the f-Met-Leu-Phe combining sites of MP-2 purified from neutrophil membranes that had been solubilized in Nonidet P40 exhibited binding constants similar in magnitude to those of the receptors in intact neutrophils, while the remainder of the sites retained a mean of 2% of the affinity of native receptors. Purified MP-2 elicited IgG antibodies predominantly to framework determinants, rather than the combining site, of the f-Met-Leu-Phe receptors. IgG antibodies, ...
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Other literature type . 1982
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