Aurintricarboxylic acid modulates the affinity of hepatitis C virus NS3 helicase for both nucleic acid and ATP‡

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Shadrick, William R.; Mukherjee, Sourav; Hanson, Alicia M.; Sweeney, Noreena L.; Frick, David N.;

Aurintricarboxylic acid (ATA) is a potent inhibitor of many enzymes needed for cell and virus replication, such as polymerases, helicases, nucleases, and topoisomerases. This study examines how ATA interacts with the helicase encoded by the hepatitis C virus (HCV) to re... View more
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