publication . Other literature type . Article . 2010

Biologically active collagen-based scaffolds: advances in processing and characterization

Yannas, I. V.; Tzeranis, D. S.; Harley, B. A.; So, P. T. C.;

Published: 28 Apr 2010

Publisher: The Royal Society

Summary

Abstract

A small number of type I collagen–glycosaminoglycan scaffolds (collagen–GAG scaffolds; CGSs) have unusual biological activity consisting primarily in inducing partial regeneration of organs in the adult mammal. Two of these are currently in use in a variety of clinical settings. CGSs appear to induce regeneration by blocking the adult healing response, following trauma, consisting of wound contraction and scar formation. Several structural determinants of biological activity have been identified, including ligands for binding of fibroblasts to the collagen surface, the mean pore size (which affects ligand density) and the degradation rate (which affects the dura...

doi: 10.1098/rsta.2010.0015

pmc: PMC2944393

pmid: 20308118

Subjects

free text keywords: General Engineering, General Physics and Astronomy, General Mathematics, Confocal, Fluorophore, chemistry.chemical_compound, chemistry, Biophysics, Glycosaminoglycan, Physics, Classical mechanics, Cellular differentiation, Photobleaching, Scaffold, Nanotechnology, Biological activity, Confocal microscopy, law.invention, law, Articles

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