Suboptimal extracellular pH values alter DNA damage response to induced double‐strand breaks

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Massonneau, Julien; Ouellet, Camille; Lucien, Fabrice; Dubois, Claire M.; Tyler, Jessica; Boissonneault, Guylain;

Conditions leading to unrepaired DNA double‐stranded breaks are potent inducers of genetic instability. Systemic conditions may lead to fluctuation of hydrogen ions in the cellular microenvironment, and we show that small variations in extracellular pH, termed suboptima... View more
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