publication . Article . 2016

KlebSeq, a Diagnostic Tool for Surveillance, Detection, and Monitoring of Klebsiella pneumoniae

Bowers, Jolene R.; Lemmer, Darrin; Sahl, Jason W.; Pearson, Talima; Driebe, Elizabeth M.; Wojack, Bette; Saubolle, Michael A.; Engelthaler, David M.; Keim, Paul;
Open Access English
  • Published: 01 Sep 2016 Journal: Journal of Clinical Microbiology, volume 54, issue 10, pages 2,582-2,596 (issn: 0095-1137, eissn: 1098-660X, Copyright policy)
  • Publisher: American Society for Microbiology
Abstract
Health care-acquired infections (HAIs) kill tens of thousands of people each year and add significantly to health care costs. Multidrug-resistant and epidemic strains are a large proportion of HAI agents, and multidrug-resistant strains of Klebsiella pneumoniae, a leading HAI agent, have caused an urgent public health crisis. In the health care environment, patient colonization by K. pneumoniae precedes infection, and transmission via colonization leads to outbreaks. Periodic patient screening for K. pneumoniae colonization has the potential to curb the number of HAIs. In this report, we describe the design and validation of KlebSeq, a highly informative screeni...
Subjects
free text keywords: Bacteriology
Funded by
NIH| Molecular Antibiotic Resistance Arrays for clinical microbiology laboratories
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01AI090782-05
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
85 references, page 1 of 6

1.Montgomerie JZ 1979 Epidemiology of Klebsiella and hospital-associated infections. Rev Infect Dis 1:736–753. doi:10.1093/clinids/1.5.736.396632 [PubMed] [DOI]

2.Magill SS, Edwards JR, Bamberg W, Beldavs ZG, Dumyati G, Kainer MA, Lynfield R, Maloney M, McAllister-Hollod L, Nadle J, Ray SM, Thompson DL, Wilson LE, Fridkin SK, Emerging Infections Program Healthcare-Associated Infections, Antimicrobial Use Prevalence Survey Team. 2014 Multistate point-prevalence survey of health care-associated infections. N Engl J Med 370:1198–1208. doi:10.1056/NEJMoa1306801.24670166 [OpenAIRE] [PubMed] [DOI]

3.Centers for Disease Control and Prevention. 2013 Antibiotic resistance threats in the United States, 2013. Centers for Disease Control and Prevention, Atlanta, GA http://www.cdc.gov/drugresistance/pdf/ar-threats-2013-508.pdf.

4.Xu Y, Gu B, Huang M, Liu H, Xu T, Xia W, Wang T 2015 Epidemiology of carbapenem resistant Enterobacteriaceae (CRE) during 2000-2012 in Asia. J Thorac Dis 7:376–385. doi:10.3978/j.issn.2072-1439.2014.12.33.25922715 [OpenAIRE] [PubMed] [DOI]

5.World Health Organization. 2014 Antimicrobial resistance global report on surveillance. World Health Organization, Geneva, Switzerland http://apps.who.int/iris/bitstream/10665/112642/1/9789241564748_eng.pdf.

6.Correa L, Martino MD, Siqueira I, Pasternak J, Gales AC, Silva CV, Camargo TZ, Scherer PF, Marra AR 2013 A hospital-based matched case-control study to identify clinical outcome and risk factors associated with carbapenem-resistant Klebsiella pneumoniae infection. BMC Infect Dis 13:80. doi:10.1186/1471-2334-13-80.23398691 [OpenAIRE] [PubMed] [DOI]

7.Kitchel B, Sundin DR, Patel JB 2009 Regional dissemination of KPC-producing Klebsiella pneumoniae. Antimicrob Agents Chemother 53:4511–4513. doi:10.1128/AAC.00784-09.19687250 [OpenAIRE] [PubMed] [DOI]

8.Frasson I, Lavezzo E, Franchin E, Toppo S, Barzon L, Cavallaro A, Richter SN, Palu G 2012 Antimicrobial treatment and containment measures for an extremely drug-resistant Klebsiella pneumoniae ST101 isolate carrying pKPN101-IT, a novel fully sequenced bla(KPC-2) plasmid. J Clin Microbiol 50:3768–3772. doi:10.1128/JCM.01892-12.22972824 [OpenAIRE] [PubMed] [DOI]

9.Lascols C, Peirano G, Hackel M, Laupland KB, Pitout JD 2013 Surveillance and molecular epidemiology of Klebsiella pneumoniae isolates that produce carbapenemases: first report of OXA-48-like enzymes in North America. Antimicrob Agents Chemother 57:130–136. doi:10.1128/AAC.01686-12.23070171 [OpenAIRE] [PubMed] [DOI]

10.Bialek-Davenet S, Criscuolo A, Ailloud F, Passet V, Jones L, Delannoy-Vieillard AS, Garin B, Le Hello S, Arlet G, Nicolas-Chanoine MH, Decre D, Brisse S 2014 Genomic definition of hypervirulent and multidrug-resistant Klebsiella pneumoniae clonal groups. Emerg Infect Dis 20:1812–1820. doi:10.3201/eid2011.140206.25341126 [OpenAIRE] [PubMed] [DOI]

11.Nagasaka Y, Kimura K, Yamada K, Wachino J, Jin W, Notake S, Yanagisawa H, Arakawa Y 2015 Genetic profiles of fluoroquinolone-nonsusceptible Klebsiella pneumoniae among cephalosporin-resistant K. pneumoniae. Microb Drug Resist 21:224–233. doi:10.1089/mdr.2014.0150.25419619 [PubMed] [DOI]

12.Liu Y, Wan LG, Deng Q, Cao XW, Yu Y, Xu QF 2015 First description of NDM-1-, KPC-2-, VIM-2- and IMP-4-producing Klebsiella pneumoniae strains in a single Chinese teaching hospital. Epidemiol Infect 143:376–384. doi:10.1017/S0950268814000995.24762211 [PubMed] [DOI]

13.Cubero M, Grau I, Tubau F, Pallares R, Dominguez MA, Linares J, Ardanuy C 2016 Hypervirulent Klebsiella pneumoniae clones causing bacteraemia in adults in a teaching hospital in Barcelona, Spain (2007-2013). Clin Microbiol Infect 22:154–160. doi:10.1016/j.cmi.2015.09.025.26454059 [OpenAIRE] [PubMed] [DOI]

14.Jacobson RK, Manesen MR, Moodley C, Smith M, Williams SG, Nicol MP, Bamford CM 2015 Molecular characterisation and epidemiological investigation of an outbreak of blaOXA-181 carbapenemase-producing isolates of Klebsiella pneumoniae in South Africa. S Afr Med J 105:1030–1035. doi:10.7196/SAMJ.2015.v105i12.9926.26792160 [OpenAIRE] [PubMed] [DOI]

15.Zhu J, Sun L, Ding B, Yang Y, Xu X, Liu W, Zhu D, Yang F, Zhang H, Hu F 2016 Outbreak of NDM-1-producing Klebsiella pneumoniae ST76 and ST37 isolates in neonates. Eur J Clin Microbiol Infect Dis doi:10.1007/s10096-016-2578-z. [DOI]

85 references, page 1 of 6
Abstract
Health care-acquired infections (HAIs) kill tens of thousands of people each year and add significantly to health care costs. Multidrug-resistant and epidemic strains are a large proportion of HAI agents, and multidrug-resistant strains of Klebsiella pneumoniae, a leading HAI agent, have caused an urgent public health crisis. In the health care environment, patient colonization by K. pneumoniae precedes infection, and transmission via colonization leads to outbreaks. Periodic patient screening for K. pneumoniae colonization has the potential to curb the number of HAIs. In this report, we describe the design and validation of KlebSeq, a highly informative screeni...
Subjects
free text keywords: Bacteriology
Funded by
NIH| Molecular Antibiotic Resistance Arrays for clinical microbiology laboratories
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01AI090782-05
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
85 references, page 1 of 6

1.Montgomerie JZ 1979 Epidemiology of Klebsiella and hospital-associated infections. Rev Infect Dis 1:736–753. doi:10.1093/clinids/1.5.736.396632 [PubMed] [DOI]

2.Magill SS, Edwards JR, Bamberg W, Beldavs ZG, Dumyati G, Kainer MA, Lynfield R, Maloney M, McAllister-Hollod L, Nadle J, Ray SM, Thompson DL, Wilson LE, Fridkin SK, Emerging Infections Program Healthcare-Associated Infections, Antimicrobial Use Prevalence Survey Team. 2014 Multistate point-prevalence survey of health care-associated infections. N Engl J Med 370:1198–1208. doi:10.1056/NEJMoa1306801.24670166 [OpenAIRE] [PubMed] [DOI]

3.Centers for Disease Control and Prevention. 2013 Antibiotic resistance threats in the United States, 2013. Centers for Disease Control and Prevention, Atlanta, GA http://www.cdc.gov/drugresistance/pdf/ar-threats-2013-508.pdf.

4.Xu Y, Gu B, Huang M, Liu H, Xu T, Xia W, Wang T 2015 Epidemiology of carbapenem resistant Enterobacteriaceae (CRE) during 2000-2012 in Asia. J Thorac Dis 7:376–385. doi:10.3978/j.issn.2072-1439.2014.12.33.25922715 [OpenAIRE] [PubMed] [DOI]

5.World Health Organization. 2014 Antimicrobial resistance global report on surveillance. World Health Organization, Geneva, Switzerland http://apps.who.int/iris/bitstream/10665/112642/1/9789241564748_eng.pdf.

6.Correa L, Martino MD, Siqueira I, Pasternak J, Gales AC, Silva CV, Camargo TZ, Scherer PF, Marra AR 2013 A hospital-based matched case-control study to identify clinical outcome and risk factors associated with carbapenem-resistant Klebsiella pneumoniae infection. BMC Infect Dis 13:80. doi:10.1186/1471-2334-13-80.23398691 [OpenAIRE] [PubMed] [DOI]

7.Kitchel B, Sundin DR, Patel JB 2009 Regional dissemination of KPC-producing Klebsiella pneumoniae. Antimicrob Agents Chemother 53:4511–4513. doi:10.1128/AAC.00784-09.19687250 [OpenAIRE] [PubMed] [DOI]

8.Frasson I, Lavezzo E, Franchin E, Toppo S, Barzon L, Cavallaro A, Richter SN, Palu G 2012 Antimicrobial treatment and containment measures for an extremely drug-resistant Klebsiella pneumoniae ST101 isolate carrying pKPN101-IT, a novel fully sequenced bla(KPC-2) plasmid. J Clin Microbiol 50:3768–3772. doi:10.1128/JCM.01892-12.22972824 [OpenAIRE] [PubMed] [DOI]

9.Lascols C, Peirano G, Hackel M, Laupland KB, Pitout JD 2013 Surveillance and molecular epidemiology of Klebsiella pneumoniae isolates that produce carbapenemases: first report of OXA-48-like enzymes in North America. Antimicrob Agents Chemother 57:130–136. doi:10.1128/AAC.01686-12.23070171 [OpenAIRE] [PubMed] [DOI]

10.Bialek-Davenet S, Criscuolo A, Ailloud F, Passet V, Jones L, Delannoy-Vieillard AS, Garin B, Le Hello S, Arlet G, Nicolas-Chanoine MH, Decre D, Brisse S 2014 Genomic definition of hypervirulent and multidrug-resistant Klebsiella pneumoniae clonal groups. Emerg Infect Dis 20:1812–1820. doi:10.3201/eid2011.140206.25341126 [OpenAIRE] [PubMed] [DOI]

11.Nagasaka Y, Kimura K, Yamada K, Wachino J, Jin W, Notake S, Yanagisawa H, Arakawa Y 2015 Genetic profiles of fluoroquinolone-nonsusceptible Klebsiella pneumoniae among cephalosporin-resistant K. pneumoniae. Microb Drug Resist 21:224–233. doi:10.1089/mdr.2014.0150.25419619 [PubMed] [DOI]

12.Liu Y, Wan LG, Deng Q, Cao XW, Yu Y, Xu QF 2015 First description of NDM-1-, KPC-2-, VIM-2- and IMP-4-producing Klebsiella pneumoniae strains in a single Chinese teaching hospital. Epidemiol Infect 143:376–384. doi:10.1017/S0950268814000995.24762211 [PubMed] [DOI]

13.Cubero M, Grau I, Tubau F, Pallares R, Dominguez MA, Linares J, Ardanuy C 2016 Hypervirulent Klebsiella pneumoniae clones causing bacteraemia in adults in a teaching hospital in Barcelona, Spain (2007-2013). Clin Microbiol Infect 22:154–160. doi:10.1016/j.cmi.2015.09.025.26454059 [OpenAIRE] [PubMed] [DOI]

14.Jacobson RK, Manesen MR, Moodley C, Smith M, Williams SG, Nicol MP, Bamford CM 2015 Molecular characterisation and epidemiological investigation of an outbreak of blaOXA-181 carbapenemase-producing isolates of Klebsiella pneumoniae in South Africa. S Afr Med J 105:1030–1035. doi:10.7196/SAMJ.2015.v105i12.9926.26792160 [OpenAIRE] [PubMed] [DOI]

15.Zhu J, Sun L, Ding B, Yang Y, Xu X, Liu W, Zhu D, Yang F, Zhang H, Hu F 2016 Outbreak of NDM-1-producing Klebsiella pneumoniae ST76 and ST37 isolates in neonates. Eur J Clin Microbiol Infect Dis doi:10.1007/s10096-016-2578-z. [DOI]

85 references, page 1 of 6
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