Antiproliferative effect of immunoliposomes containing 5-fluorodeoxyuridine-dipalmitate on colon cancer cells

Article English OPEN
Koning, G A; Gorter, A; Scherphof, G L; Kamps, J A A M; (1999)
  • Publisher: Nature Publishing Group
  • Journal: British Journal of Cancer,volume 80,issue 11,pages1,718-1,725 (issn: 0007-0920, eissn: 1532-1827)
  • Related identifiers: doi: 10.1038/sj.bjc.6690588, pmc: PMC2363118
  • Subject: Regular Article | immunoliposomes | monoclonal antibody | colon cancer | tumour targeting | 5-fluorodeoxyuridine | drug delivery

We have investigated the antiproliferative action towards CC531 colon adenocarcinoma cells of target cell-specific immunoliposomes containing the amphiphilic dipalmitoyl derivative of 5-fluorodeoxyuridine (FUdR-dP). FUdR-dP incorporated in immunoliposomes caused a 13-fo... View more
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