A novel single‐cell method provides direct evidence of persistent DNA damage in senescent cells and aged mammalian tissues

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Galbiati, Alessandro; Beauséjour, Christian; d'Adda di Fagagna, Fabrizio;
(2017)
  • Publisher: John Wiley and Sons Inc.
  • Journal: Aging Cell,volume 16,issue 2,pages422-427 (issn: 1474-9718, eissn: 1474-9726)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1111/acel.12573, pmc: PMC5334542
  • Subject: cellular senescence | DNA damage in situ proximity ligation assay | Short Take | DNA damage | DNA damage response | aging | DNA segments with chromatin alterations reinforcing senescence
    mesheuropmc: body regions

Summary The DNA damage response (DDR) arrests cell cycle progression until DNA lesions, like DNA double‐strand breaks (DSBs), are repaired. The presence of DSBs in cells is usually detected by indirect techniques that rely on the accumulation of proteins at DSBs, as par... View more
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