Toll‐Like Receptor 9 Plays a Pivotal Role in Angiotensin II–Induced Atherosclerosis

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Fukuda, Daiju; Nishimoto, Sachiko; Aini, Kunduziayi; Tanaka, Atsushi; Nishiguchi, Tsuyoshi; Kim‐Kaneyama, Joo‐ri; Lei, Xiao‐Feng; Masuda, Kiyoshi; Naruto, Takuya; Tanaka, Kimie; Higashikuni, Yasutomi; Hirata, Yoichiro; Yagi, Shusuke; Kusunose, Kenya; Yamada, Hirotsugu; Soeki, Takeshi; Imoto, Issei; Akasaka, Takashi; Shimabukuro, Michio; Sata, Masataka;
(2019)
  • Publisher: John Wiley and Sons Inc.
  • Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease,volume 8,issue 7 (eissn: 2047-9980)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1161/JAHA.118.010860, pmc: PMC6509720
  • Subject: Original Research | Original Research | Vascular Medicine | atherosclerosis | inflammation | macrophage | Toll‐like receptor 9 | vascular inflammation | Basic Science Research | Inflammation | Vascular Biology | Atherosclerosis

Background Toll‐like receptor (TLR) 9 recognizes bacterial DNA, activating innate immunity, whereas it also provokes inflammation in response to fragmented DNA released from mammalian cells. We investigated whether TLR9 contributes to the development of vascular inflamm... View more
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