publication . Article . 2012

inhibitory effects of anthocyanins on secretion of helicobacter pylori caga and vaca toxins

Kim, Sa-Hyun; Park, Min; Woo, Hyunjun; Tharmalingam, Nagendran; Lee, Gyusang; Rhee, Ki-Jong; Eom, Yong Bin; Han, Sang Ik; Seo, Woo Duck; Kim, Jong Bae;
Open Access
  • Published: 01 Nov 2012 Journal: International Journal of Medical Sciences, volume 9, pages 838-842 (issn: 1449-1907, Copyright policy)
  • Publisher: Ivyspring International Publisher
Abstract
Anthocyanins have been studied as potential antimicrobial agents against Helicobacter pylori. We investigated whether the biosynthesis and secretion of cytotoxin-associated protein A (CagA) and vacuolating cytotoxin A (VacA) could be suppressed by anthocyanin treatment in vitro. H. pylori reference strain 60190 (CagA+/VacA+) was used in this study to investigate the inhibitory effects of anthocyanins; cyanidin 3-O-glucoside (C3G), peonidin 3-O-glucoside (Peo3G), pelargonidin 3-O-glucoside (Pel3G), and malvidin 3-O-glucoside (M3G) on expression and secretion of H. pylori toxins. Anthocyanins were added to bacterial cultures and Western blotting was used to determ...
Subjects
Medical Subject Headings: bacteriabacterial infections and mycosesdigestive system diseases
free text keywords: General Medicine, Pelargonidin, chemistry.chemical_compound, chemistry, In vitro, Protein A, biology.protein, biology, Helicobacter pylori, biology.organism_classification, Microbiology, Molecular biology, Toxin, medicine.disease_cause, medicine, Secretion, Blot, CagA, Short Research Communication, VacA, SecA, anthocyanin, cyanidin 3-O-glucoside.
Related Organizations
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publication . Article . 2012

inhibitory effects of anthocyanins on secretion of helicobacter pylori caga and vaca toxins

Kim, Sa-Hyun; Park, Min; Woo, Hyunjun; Tharmalingam, Nagendran; Lee, Gyusang; Rhee, Ki-Jong; Eom, Yong Bin; Han, Sang Ik; Seo, Woo Duck; Kim, Jong Bae;