publication . Other literature type . 2014

Microplate-based screening for small molecule inhibitors of Neuropilin-2/VEGF-C interactions

Parker, Matthew W.; Kooi, Craig W. Vander;
Open Access English
  • Published: 26 Feb 2014
Vascular Endothelial Growth Factor-C (VEGF-C) is a secreted growth factor essential for lymphangiogenesis. VEGF-C functions in both physiological and pathological lymphangiogenesis, particularly in tumor metastasis, making it an attractive therapeutic target. Members of two families of cell surface receptors transduce VEGF-C signals, Neuropilin-2 (Nrp2) and VEGF-receptor (VEGFR)-2/3. Nrp2 is a promising target for inhibition since it is highly expressed in lymphatic vessels. Here we describe a microplate-based assay for discovery of VEGF-C/Nrp2 inhibitors. We optimize this assay for use in screening an inhibitor library and identify three novel Nrp2/VEGF-C bindi...
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Other literature type . 2014
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