Exploration of α1-Antitrypsin Treatment Protocol for Islet Transplantation: Dosing Plan and Route of Administration

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Baranovski, Boris M.; Ozeri, Eyal; Shahaf, Galit; Ochayon, David E.; Schuster, Ronen; Bahar, Nofar; Kalay, Noa; Cal, Pablo; Mizrahi, Mark I.; Nisim, Omer; Strauss, Pnina; Schenker, Eran; Lewis, Eli C.;
  • Publisher: The American Society for Pharmacology and Experimental Therapeutics
  • Journal: The Journal of Pharmacology and Experimental Therapeutics,volume 359,issue 3,pages482-490 (issn: 0022-3565, eissn: 1521-0103)
  • Related identifiers: pmc: PMC5118642, doi: 10.1124/jpet.116.236067
  • Subject: Inflammation, Immunopharmacology, and Asthma

Lifelong weekly infusions of human α1-antitrypsin (hAAT) are currently administered as augmentation therapy for patients with genetic AAT deficiency (AATD). Several recent clinical trials attempt to extend hAAT therapy to conditions outside AATD, including type 1 diabet... View more
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