Exploration of α1-Antitrypsin Treatment Protocol for Islet Transplantation: Dosing Plan and Route of Administration

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Baranovski, Boris M. ; Ozeri, Eyal ; Shahaf, Galit ; Ochayon, David E. ; Schuster, Ronen ; Bahar, Nofar ; Kalay, Noa ; Cal, Pablo ; Mizrahi, Mark I. ; Nisim, Omer ; Strauss, Pnina ; Schenker, Eran ; Lewis, Eli C. (2016)
  • Publisher: The American Society for Pharmacology and Experimental Therapeutics
  • Journal: The Journal of Pharmacology and Experimental Therapeutics, volume 359, issue 3, pages 482-490 (issn: 0022-3565, eissn: 1521-0103)
  • Related identifiers: pmc: PMC5118642, doi: 10.1124/jpet.116.236067
  • Subject: Inflammation, Immunopharmacology, and Asthma

Lifelong weekly infusions of human α1-antitrypsin (hAAT) are currently administered as augmentation therapy for patients with genetic AAT deficiency (AATD). Several recent clinical trials attempt to extend hAAT therapy to conditions outside AATD, including type 1 diabet... View more
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