publication . Article . Other literature type . 2007

Regulation of hepatic bile acid transporters Ntcp and Bsep expression.

Cheng, Xingguo; Buckley, David; Klaassen, Curtis D.;
Open Access
  • Published: 19 Aug 2007 Journal: Biochemical Pharmacology, volume 74, pages 1,665-1,676 (issn: 0006-2952, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Sodium-taurocholate cotransporting polypeptide (Ntcp) and bile salt export pump (Bsep) are two key transporters for hepatic bile acid uptake and excretion. Alterations in Ntcp and Bsep expression have been reported in pathophysiological conditions. In the present study, the effects of age, gender, and various chemicals on the regulation of these two transporters were characterized in mice. Ntcp and Bsep mRNA levels in mouse liver were low in the fetus, but increased to its highest expression at parturition. After birth, mouse Ntcp and Bsep mRNA decreased by more than 50%, and then gradually increased to adult levels by day 30. Expression of mouse Ntcp mRNA and p...
Subjects
Medical Subject Headings: digestive system
free text keywords: Biochemistry, Pharmacology, Cholestyramine, medicine.drug, medicine, Hormone, Chenodeoxycholic acid, chemistry.chemical_compound, chemistry, Enzyme inducer, biology.protein, biology, Endocrinology, medicine.medical_specialty, Symporter, Bile Salt Export Pump, Cholesterol, Internal medicine, Bile acid, medicine.drug_class, Article
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