publication . Article . 2017

Multiparametric analysis of anti-proliferative and apoptotic effects of gold nanoprisms on mouse and human primary and transformed cells, biodistribution and toxicity in vivo

Pérez-Hernández, Marta; Moros, María; Stepien, Grazyna; del Pino, Pablo; Menao, Sebastián; de las Heras, Marcelo; Arias, Maykel; Mitchell, Scott G.; Pelaz, Beatriz; Gálvez, Eva M.; ...
Open Access English
  • Published: 01 Oct 2017 Journal: Particle and Fibre Toxicology (issn: 1743-8977, Copyright policy)
  • Publisher: BMC
Abstract
[Background]: The special physicochemical properties of gold nanoprisms make them very useful for biomedical applications including biosensing and cancer therapy. However, it is not clear how gold nanoprisms may affect cellular physiology including viability and other critical functions. We report a multiparametric investigation on the impact of gold-nanoprisms on mice and human, transformed and primary cells as well as tissue distribution and toxicity in vivo after parental injection.
Subjects
free text keywords: Gold nanoprisms, Nanotoxicology, ROS generation, Mitochondrial membrane-potential, Biodistribution, In vivo, Toxicology. Poisons, RA1190-1270, Industrial hygiene. Industrial welfare, HD7260-7780.8, Research, Toxicity, Toxicology, Cell morphology, Cell culture, Cell growth, Materials science, Cell physiology, Cell, medicine.anatomical_structure, medicine, A549 cell
Funded by
EC| HyHeat
Project
HyHeat
Profiling gene expression in Hydra vulgaris following Gold Nanoparticle-mediated hyperthermia
  • Funder: European Commission (EC)
  • Project Code: 660228
  • Funding stream: H2020 | MSCA-IF-EF-ST
,
EC| NANOPUZZLE
Project
NANOPUZZLE
Multifunctional Magnetic Nanoparticles: Towards Smart Drugs Design.
  • Funder: European Commission (EC)
  • Project Code: 239931
  • Funding stream: FP7 | SP2 | ERC
,
EC| HOTFLOW
Project
HOTFLOW
A Photothermal Lateral Flow Test for Visual Point of Care Detection
  • Funder: European Commission (EC)
  • Project Code: 754609
  • Funding stream: H2020 | ERC | ERC-POC
58 references, page 1 of 4

Holzinger, M, Le Goff, A, Cosnier, S. Nanomaterials for biosensing applications: a review. Front Chem. 2014; 2: 63 [OpenAIRE] [PubMed] [DOI]

Verma, J, Lal, S, Van Noorden, CJ. Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma. Int J Nanomedicine. 2014; 9: 2863-2877 [OpenAIRE] [PubMed]

Pelaz, B, Alexiou, C, Alvarez-Puebla, RA, Alves, F, Andrews, AM, Ashraf, S, Balogh, LP, Ballerini, L, Bestetti, A, Brendel, C. Diverse applications of nanomedicine. ACS Nano. 2017; 11: 2313-2381 [OpenAIRE] [PubMed] [DOI]

Abadeer, NS, Murphy, CJ. Recent progress in cancer thermal therapy using gold nanoparticles. J Phys Chem C. 2016; 120: 4691-4716 [OpenAIRE] [DOI]

Alkilany, AM, Thompson, LB, Boulos, SP, Sisco, PN, Murphy, CJ. Gold nanorods: their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions. Adv Drug Deliv Rev. 2012; 64: 190-199 [OpenAIRE] [PubMed] [DOI]

Huschka, R, Barhoumi, A, Liu, Q, Roth, JA, Ji, L, Halas, NJ. Gene silencing by gold nanoshell-mediated delivery and laser-triggered release of antisense oligonucleotide and siRNA. ACS Nano. 2012; 6: 7681-7691 [OpenAIRE] [PubMed] [DOI]

Pelaz, B, Grazu, V, Ibarra, A, Magen, C, del Pino, P, de la Fuente, JM. Tailoring the synthesis and heating ability of gold nanoprisms for bioapplications. Langmuir. 2012; 28: 8965-8970 [OpenAIRE] [PubMed] [DOI]

Perez-Hernandez, M, Del Pino, P, Mitchell, SG, Moros, M, Stepien, G, Pelaz, B, Parak, WJ, Galvez, EM, Pardo, J, de la Fuente, JM. Dissecting the molecular mechanism of apoptosis during photothermal therapy using gold nanoprisms. ACS Nano. 2015; 9: 52-61 [OpenAIRE] [PubMed] [DOI]

Albanese, A, Sykes, EA, Chan, WC. Rough around the edges: the inflammatory response of microglial cells to spiky nanoparticles. ACS Nano. 2010; 4: 2490-2493 [OpenAIRE] [PubMed] [DOI]

Arvizo, RR, Bhattacharyya, S, Kudgus, RA, Giri, K, Bhattacharya, R, Mukherjee, P. Intrinsic therapeutic applications of noble metal nanoparticles: past, present and future. Chem Soc Rev. 2012; 41: 2943-2970 [OpenAIRE] [PubMed] [DOI]

Dreaden, EC, Alkilany, AM, Huang, X, Murphy, CJ, El-Sayed, MA. The golden age: gold nanoparticles for biomedicine. Chem Soc Rev. 2012; 41: 2740-2779 [OpenAIRE] [PubMed] [DOI]

Pelaz, B, Charron, G, Pfeiffer, C, Zhao, Y, de la Fuente, JM, Liang, XJ, Parak, WJ, Del Pino, P. Interfacing engineered nanoparticles with biological systems: anticipating adverse nano-bio interactions. Small. 2013; 9: 1573-1584 [OpenAIRE] [PubMed] [DOI]

Qin, Z, Bischof, JC. Thermophysical and biological responses of gold nanoparticle laser heating. Chem Soc Rev. 2012; 41: 1191-1217 [PubMed] [DOI]

Rivera-Gil, P, Jimenez de Aberasturi, D, Wulf, V, Pelaz, B, del Pino, P, Zhao, Y, de la Fuente, JM, Ruiz de Larramendi, I, Rojo, T, Liang, XJ, Parak, WJ. The challenge to relate the physicochemical properties of colloidal nanoparticles to their cytotoxicity. Acc Chem Res. 2013; 46: 743-749 [OpenAIRE] [PubMed] [DOI]

Nel, AE, Madler, L, Velegol, D, Xia, T, Hoek, EM, Somasundaran, P, Klaessig, F, Castranova, V, Thompson, M. Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater. 2009; 8: 543-557 [OpenAIRE] [PubMed] [DOI]

58 references, page 1 of 4
Abstract
[Background]: The special physicochemical properties of gold nanoprisms make them very useful for biomedical applications including biosensing and cancer therapy. However, it is not clear how gold nanoprisms may affect cellular physiology including viability and other critical functions. We report a multiparametric investigation on the impact of gold-nanoprisms on mice and human, transformed and primary cells as well as tissue distribution and toxicity in vivo after parental injection.
Subjects
free text keywords: Gold nanoprisms, Nanotoxicology, ROS generation, Mitochondrial membrane-potential, Biodistribution, In vivo, Toxicology. Poisons, RA1190-1270, Industrial hygiene. Industrial welfare, HD7260-7780.8, Research, Toxicity, Toxicology, Cell morphology, Cell culture, Cell growth, Materials science, Cell physiology, Cell, medicine.anatomical_structure, medicine, A549 cell
Funded by
EC| HyHeat
Project
HyHeat
Profiling gene expression in Hydra vulgaris following Gold Nanoparticle-mediated hyperthermia
  • Funder: European Commission (EC)
  • Project Code: 660228
  • Funding stream: H2020 | MSCA-IF-EF-ST
,
EC| NANOPUZZLE
Project
NANOPUZZLE
Multifunctional Magnetic Nanoparticles: Towards Smart Drugs Design.
  • Funder: European Commission (EC)
  • Project Code: 239931
  • Funding stream: FP7 | SP2 | ERC
,
EC| HOTFLOW
Project
HOTFLOW
A Photothermal Lateral Flow Test for Visual Point of Care Detection
  • Funder: European Commission (EC)
  • Project Code: 754609
  • Funding stream: H2020 | ERC | ERC-POC
58 references, page 1 of 4

Holzinger, M, Le Goff, A, Cosnier, S. Nanomaterials for biosensing applications: a review. Front Chem. 2014; 2: 63 [OpenAIRE] [PubMed] [DOI]

Verma, J, Lal, S, Van Noorden, CJ. Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma. Int J Nanomedicine. 2014; 9: 2863-2877 [OpenAIRE] [PubMed]

Pelaz, B, Alexiou, C, Alvarez-Puebla, RA, Alves, F, Andrews, AM, Ashraf, S, Balogh, LP, Ballerini, L, Bestetti, A, Brendel, C. Diverse applications of nanomedicine. ACS Nano. 2017; 11: 2313-2381 [OpenAIRE] [PubMed] [DOI]

Abadeer, NS, Murphy, CJ. Recent progress in cancer thermal therapy using gold nanoparticles. J Phys Chem C. 2016; 120: 4691-4716 [OpenAIRE] [DOI]

Alkilany, AM, Thompson, LB, Boulos, SP, Sisco, PN, Murphy, CJ. Gold nanorods: their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions. Adv Drug Deliv Rev. 2012; 64: 190-199 [OpenAIRE] [PubMed] [DOI]

Huschka, R, Barhoumi, A, Liu, Q, Roth, JA, Ji, L, Halas, NJ. Gene silencing by gold nanoshell-mediated delivery and laser-triggered release of antisense oligonucleotide and siRNA. ACS Nano. 2012; 6: 7681-7691 [OpenAIRE] [PubMed] [DOI]

Pelaz, B, Grazu, V, Ibarra, A, Magen, C, del Pino, P, de la Fuente, JM. Tailoring the synthesis and heating ability of gold nanoprisms for bioapplications. Langmuir. 2012; 28: 8965-8970 [OpenAIRE] [PubMed] [DOI]

Perez-Hernandez, M, Del Pino, P, Mitchell, SG, Moros, M, Stepien, G, Pelaz, B, Parak, WJ, Galvez, EM, Pardo, J, de la Fuente, JM. Dissecting the molecular mechanism of apoptosis during photothermal therapy using gold nanoprisms. ACS Nano. 2015; 9: 52-61 [OpenAIRE] [PubMed] [DOI]

Albanese, A, Sykes, EA, Chan, WC. Rough around the edges: the inflammatory response of microglial cells to spiky nanoparticles. ACS Nano. 2010; 4: 2490-2493 [OpenAIRE] [PubMed] [DOI]

Arvizo, RR, Bhattacharyya, S, Kudgus, RA, Giri, K, Bhattacharya, R, Mukherjee, P. Intrinsic therapeutic applications of noble metal nanoparticles: past, present and future. Chem Soc Rev. 2012; 41: 2943-2970 [OpenAIRE] [PubMed] [DOI]

Dreaden, EC, Alkilany, AM, Huang, X, Murphy, CJ, El-Sayed, MA. The golden age: gold nanoparticles for biomedicine. Chem Soc Rev. 2012; 41: 2740-2779 [OpenAIRE] [PubMed] [DOI]

Pelaz, B, Charron, G, Pfeiffer, C, Zhao, Y, de la Fuente, JM, Liang, XJ, Parak, WJ, Del Pino, P. Interfacing engineered nanoparticles with biological systems: anticipating adverse nano-bio interactions. Small. 2013; 9: 1573-1584 [OpenAIRE] [PubMed] [DOI]

Qin, Z, Bischof, JC. Thermophysical and biological responses of gold nanoparticle laser heating. Chem Soc Rev. 2012; 41: 1191-1217 [PubMed] [DOI]

Rivera-Gil, P, Jimenez de Aberasturi, D, Wulf, V, Pelaz, B, del Pino, P, Zhao, Y, de la Fuente, JM, Ruiz de Larramendi, I, Rojo, T, Liang, XJ, Parak, WJ. The challenge to relate the physicochemical properties of colloidal nanoparticles to their cytotoxicity. Acc Chem Res. 2013; 46: 743-749 [OpenAIRE] [PubMed] [DOI]

Nel, AE, Madler, L, Velegol, D, Xia, T, Hoek, EM, Somasundaran, P, Klaessig, F, Castranova, V, Thompson, M. Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater. 2009; 8: 543-557 [OpenAIRE] [PubMed] [DOI]

58 references, page 1 of 4
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publication . Article . 2017

Multiparametric analysis of anti-proliferative and apoptotic effects of gold nanoprisms on mouse and human primary and transformed cells, biodistribution and toxicity in vivo

Pérez-Hernández, Marta; Moros, María; Stepien, Grazyna; del Pino, Pablo; Menao, Sebastián; de las Heras, Marcelo; Arias, Maykel; Mitchell, Scott G.; Pelaz, Beatriz; Gálvez, Eva M.; ...