publication . Article . 2016

Bipolar Disorder Associated microRNA, miR-1908-5p, Regulates the Expression of Genes Functioning in Neuronal Glutamatergic Synapses

Kim, Yoonhee; Zhang, Yinhua; Pang, Kaifang; Kang, Hyojin; Park, Heejoo; Lee, Yeunkum; Lee, Bokyoung; Lee, Heon-Jeong; Kim, Won-Ki; Geum, Dongho; ...
Open Access
  • Published: 31 Dec 2016 Journal: Experimental Neurobiology, volume 25, pages 296-306 (issn: 1226-2560, eissn: 2093-8144, Copyright policy)
  • Publisher: The Korean Society for Brain and Neural Science
Abstract
Bipolar disorder (BD), characterized by recurrent mood swings between depression and mania, is a highly heritable and devastating mental illness with poorly defined pathophysiology. Recent genome-wide molecular genetic studies have identified several protein-coding genes and microRNAs (miRNAs) significantly associated with BD. Notably, some of the proteins expressed from BD-associated genes function in neuronal synapses, suggesting that abnormalities in synaptic function could be one of the key pathogenic mechanisms of BD. In contrast, however, the role of BD-associated miRNAs in disease pathogenesis remains largely unknown, mainly because of a lack of understan...
Subjects
free text keywords: Cellular and Molecular Neuroscience, Clinical Neurology, Neural stem cell, Glutamatergic, Glutamatergic synapse, Neuroscience, Synapse, DLGAP4, STX1A, microRNA, Human brain, medicine.anatomical_structure, medicine, Biology, Original Article, Bipolar disorder, miR-1908-5p
51 references, page 1 of 4

Kleinman, L, Lowin, A, Flood, E, Gandhi, G, Edgell, E, Revicki, D. Costs of bipolar disorder. Pharmacoeconomics. 2003; 21: 601-622 [PubMed]

Ferreira, MA, O'Donovan, MC, Meng, YA, Jones, IR, Ruderfer, DM, Jones, L, Fan, J, Kirov, G, Perlis, RH, Green, EK, Smoller, JW, Grozeva, D, Stone, J, Nikolov, I, Chambert, K, Hamshere, ML, Nimgaonkar, VL, Moskvina, V, Thase, ME, Caesar, S, Sachs, GS, Franklin, J, Gordon-Smith, K, Ardlie, KG, Gabriel, SB, Fraser, C, Blumenstiel, B, Defelice, M, Breen, G, Gill, M, Morris, DW, Elkin, A, Muir, WJ, McGhee, KA, Williamson, R, MacIntyre, DJ, MacLean, AW, St, CD, Robinson, M, Van Beck, M, Pereira, AC, Kandaswamy, R, McQuillin, A, Collier, DA, Bass, NJ, Young, AH, Lawrence, J, Ferrier, IN, Anjorin, A, Farmer, A, Curtis, D, Scolnick, EM, McGuffin, P, Daly, MJ, Corvin, AP, Holmans, PA, Blackwood, DH, Gurling, HM, Owen, MJ, Purcell, SM, Sklar, P, Craddock, N. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet. 2008; 40: 1056-1058 [OpenAIRE] [PubMed]

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011; 43: 977-983 [OpenAIRE] [PubMed]

Mühleisen, TW, Leber, M, Schulze, TG, Strohmaier, J, Degenhardt, F, Treutlein, J, Mattheisen, M, Forstner, AJ, Schumacher, J, Breuer, R, Meier, S, Herms, S, Hoffmann, P, Lacour, A, Witt, SH, Reif, A, Müller-Myhsok, B, Lucae, S, Maier, W, Schwarz, M, Vedder, H, Kammerer-Ciernioch, J, Pfennig, A, Bauer, M, Hautzinger, M, Moebus, S, Priebe, L, Czerski, PM, Hauser, J, Lissowska, J, Szeszenia-Dabrowska, N, Brennan, P, McKay, JD, Wright, A, Mitchell, PB, Fullerton, JM, Schofield, PR, Montgomery, GW, Medland, SE, Gordon, SD, Martin, NG, Krasnow, V, Chuchalin, A, Babadjanova, G, Pantelejeva, G, Abramova, LI, Tiganov, AS, Polonikov, A, Khusnutdinova, E, Alda, M, Grof, P, Rouleau, GA, Turecki, G, Laprise, C, Rivas, F, Mayoral, F, Kogevinas, M, Grigoroiu-Serbanescu, M, Propping, P, Becker, T, Rietschel, M, Nöthen, MM, Cichon, S. Genome-wide association study reveals two new risk loci for bipolar disorder. Nat Commun. 2014; 5: 3339 [OpenAIRE] [PubMed]

Smith, KR, Kopeikina, KJ, Fawcett-Patel, JM, Leaderbrand, K, Gao, R, Schürmann, B, Myczek, K, Radulovic, J, Swanson, GT, Penzes, P. Psychiatric risk factor ANK3/ankyrin-G nanodomains regulate the structure and function of glutamatergic synapses. Neuron. 2014; 84: 399-415 [OpenAIRE] [PubMed]

Harrison, PJ, Cipriani, A, Harmer, CJ, Nobre, AC, Saunders, K, Goodwin, GM, Geddes, JR. Innovative approaches to bipolar disorder and its treatment. Ann N Y Acad Sci. 2016; 1366: 76-89 [OpenAIRE] [PubMed]

Pennington, K, Beasley, CL, Dicker, P, Fagan, A, English, J, Pariante, CM, Wait, R, Dunn, MJ, Cotter, DR. Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder. Mol Psychiatry. 2008; 13: 1102-1117 [PubMed]

Choi, SY, Han, K. Emerging role of synaptic actin-regulatory pathway in the pathophysiology of mood disorders. Animal Cells Syst (Seoul). 2015; 19: 283-288

Kim, HW, Rapoport, SI, Rao, JS. Altered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients. Neurobiol Dis. 2010; 37: 596-603 [OpenAIRE] [PubMed]

Han, K, Holder, JL, Schaaf, CP, Lu, H, Chen, H, Kang, H, Tang, J, Wu, Z, Hao, S, Cheung, SW, Yu, P, Sun, H, Breman, AM, Patel, A, Lu, HC, Zoghbi, HY. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature. 2013; 503: 72-77 [OpenAIRE] [PubMed]

Bartel, DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009; 136: 215-233 [OpenAIRE] [PubMed]

Kim, AH, Reimers, M, Maher, B, Williamson, V, McMichael, O, McClay, JL, van den Oord, EJ, Riley, BP, Kendler, KS, Vladimirov, VI. MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders. Schizophr Res. 2010; 124: 183-191 [OpenAIRE] [PubMed]

Smalheiser, NR, Lugli, G, Zhang, H, Rizavi, H, Cook, EH, Dwivedi, Y. Expression of microRNAs and other small RNAs in prefrontal cortex in schizophrenia, bipolar disorder and depressed subjects. PLoS One. 2014; 9: e86469 [OpenAIRE] [PubMed]

Rong, H, Liu, TB, Yang, KJ, Yang, HC, Wu, DH, Liao, CP, Hong, F, Yang, HZ, Wan, F, Ye, XY, Xu, D, Zhang, X, Chao, CA, Shen, QJ. MicroRNA-134 plasma levels before and after treatment for bipolar mania. J Psychiatr Res. 2011; 45: 92-95 [OpenAIRE] [PubMed]

Forstner, AJ, Hofmann, A, Maaser, A, Sumer, S, Khudayberdiev, S, Mühleisen, TW, Leber, M, Schulze, TG, Strohmaier, J, Degenhardt, F, Treutlein, J, Mattheisen, M, Schumacher, J, Breuer, R, Meier, S, Herms, S, Hoffmann, P, Lacour, A, Witt, SH, Reif, A, Müller-Myhsok, B, Lucae, S, Maier, W, Schwarz, M, Vedder, H, Kammerer-Ciernioch, J, Pfennig, A, Bauer, M, Hautzinger, M, Moebus, S, Priebe, L, Sivalingam, S, Verhaert, A, Schulz, H, Czerski, PM, Hauser, J, Lissowska, J, Szeszenia-Dabrowska, N, Brennan, P, McKay, JD, Wright, A, Mitchell, PB, Fullerton, JM, Schofield, PR, Montgomery, GW, Medland, SE, Gordon, SD, Martin, NG, Krasnov, V, Chuchalin, A, Babadjanova, G, Pantelejeva, G, Abramova, LI, Tiganov, AS, Polonikov, A, Khusnutdinova, E, Alda, M, Cruceanu, C, Rouleau, GA, Turecki, G, Laprise, C, Rivas, F, Mayoral, F, Kogevinas, M, Grigoroiu-Serbanescu, M, Propping, P, Becker, T, Rietschel, M, Cichon, S, Schratt, G, Nöthen, MM. Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder. Transl Psychiatry. 2015; 5: e678 [OpenAIRE] [PubMed]

51 references, page 1 of 4
Abstract
Bipolar disorder (BD), characterized by recurrent mood swings between depression and mania, is a highly heritable and devastating mental illness with poorly defined pathophysiology. Recent genome-wide molecular genetic studies have identified several protein-coding genes and microRNAs (miRNAs) significantly associated with BD. Notably, some of the proteins expressed from BD-associated genes function in neuronal synapses, suggesting that abnormalities in synaptic function could be one of the key pathogenic mechanisms of BD. In contrast, however, the role of BD-associated miRNAs in disease pathogenesis remains largely unknown, mainly because of a lack of understan...
Subjects
free text keywords: Cellular and Molecular Neuroscience, Clinical Neurology, Neural stem cell, Glutamatergic, Glutamatergic synapse, Neuroscience, Synapse, DLGAP4, STX1A, microRNA, Human brain, medicine.anatomical_structure, medicine, Biology, Original Article, Bipolar disorder, miR-1908-5p
51 references, page 1 of 4

Kleinman, L, Lowin, A, Flood, E, Gandhi, G, Edgell, E, Revicki, D. Costs of bipolar disorder. Pharmacoeconomics. 2003; 21: 601-622 [PubMed]

Ferreira, MA, O'Donovan, MC, Meng, YA, Jones, IR, Ruderfer, DM, Jones, L, Fan, J, Kirov, G, Perlis, RH, Green, EK, Smoller, JW, Grozeva, D, Stone, J, Nikolov, I, Chambert, K, Hamshere, ML, Nimgaonkar, VL, Moskvina, V, Thase, ME, Caesar, S, Sachs, GS, Franklin, J, Gordon-Smith, K, Ardlie, KG, Gabriel, SB, Fraser, C, Blumenstiel, B, Defelice, M, Breen, G, Gill, M, Morris, DW, Elkin, A, Muir, WJ, McGhee, KA, Williamson, R, MacIntyre, DJ, MacLean, AW, St, CD, Robinson, M, Van Beck, M, Pereira, AC, Kandaswamy, R, McQuillin, A, Collier, DA, Bass, NJ, Young, AH, Lawrence, J, Ferrier, IN, Anjorin, A, Farmer, A, Curtis, D, Scolnick, EM, McGuffin, P, Daly, MJ, Corvin, AP, Holmans, PA, Blackwood, DH, Gurling, HM, Owen, MJ, Purcell, SM, Sklar, P, Craddock, N. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet. 2008; 40: 1056-1058 [OpenAIRE] [PubMed]

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011; 43: 977-983 [OpenAIRE] [PubMed]

Mühleisen, TW, Leber, M, Schulze, TG, Strohmaier, J, Degenhardt, F, Treutlein, J, Mattheisen, M, Forstner, AJ, Schumacher, J, Breuer, R, Meier, S, Herms, S, Hoffmann, P, Lacour, A, Witt, SH, Reif, A, Müller-Myhsok, B, Lucae, S, Maier, W, Schwarz, M, Vedder, H, Kammerer-Ciernioch, J, Pfennig, A, Bauer, M, Hautzinger, M, Moebus, S, Priebe, L, Czerski, PM, Hauser, J, Lissowska, J, Szeszenia-Dabrowska, N, Brennan, P, McKay, JD, Wright, A, Mitchell, PB, Fullerton, JM, Schofield, PR, Montgomery, GW, Medland, SE, Gordon, SD, Martin, NG, Krasnow, V, Chuchalin, A, Babadjanova, G, Pantelejeva, G, Abramova, LI, Tiganov, AS, Polonikov, A, Khusnutdinova, E, Alda, M, Grof, P, Rouleau, GA, Turecki, G, Laprise, C, Rivas, F, Mayoral, F, Kogevinas, M, Grigoroiu-Serbanescu, M, Propping, P, Becker, T, Rietschel, M, Nöthen, MM, Cichon, S. Genome-wide association study reveals two new risk loci for bipolar disorder. Nat Commun. 2014; 5: 3339 [OpenAIRE] [PubMed]

Smith, KR, Kopeikina, KJ, Fawcett-Patel, JM, Leaderbrand, K, Gao, R, Schürmann, B, Myczek, K, Radulovic, J, Swanson, GT, Penzes, P. Psychiatric risk factor ANK3/ankyrin-G nanodomains regulate the structure and function of glutamatergic synapses. Neuron. 2014; 84: 399-415 [OpenAIRE] [PubMed]

Harrison, PJ, Cipriani, A, Harmer, CJ, Nobre, AC, Saunders, K, Goodwin, GM, Geddes, JR. Innovative approaches to bipolar disorder and its treatment. Ann N Y Acad Sci. 2016; 1366: 76-89 [OpenAIRE] [PubMed]

Pennington, K, Beasley, CL, Dicker, P, Fagan, A, English, J, Pariante, CM, Wait, R, Dunn, MJ, Cotter, DR. Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder. Mol Psychiatry. 2008; 13: 1102-1117 [PubMed]

Choi, SY, Han, K. Emerging role of synaptic actin-regulatory pathway in the pathophysiology of mood disorders. Animal Cells Syst (Seoul). 2015; 19: 283-288

Kim, HW, Rapoport, SI, Rao, JS. Altered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients. Neurobiol Dis. 2010; 37: 596-603 [OpenAIRE] [PubMed]

Han, K, Holder, JL, Schaaf, CP, Lu, H, Chen, H, Kang, H, Tang, J, Wu, Z, Hao, S, Cheung, SW, Yu, P, Sun, H, Breman, AM, Patel, A, Lu, HC, Zoghbi, HY. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature. 2013; 503: 72-77 [OpenAIRE] [PubMed]

Bartel, DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009; 136: 215-233 [OpenAIRE] [PubMed]

Kim, AH, Reimers, M, Maher, B, Williamson, V, McMichael, O, McClay, JL, van den Oord, EJ, Riley, BP, Kendler, KS, Vladimirov, VI. MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders. Schizophr Res. 2010; 124: 183-191 [OpenAIRE] [PubMed]

Smalheiser, NR, Lugli, G, Zhang, H, Rizavi, H, Cook, EH, Dwivedi, Y. Expression of microRNAs and other small RNAs in prefrontal cortex in schizophrenia, bipolar disorder and depressed subjects. PLoS One. 2014; 9: e86469 [OpenAIRE] [PubMed]

Rong, H, Liu, TB, Yang, KJ, Yang, HC, Wu, DH, Liao, CP, Hong, F, Yang, HZ, Wan, F, Ye, XY, Xu, D, Zhang, X, Chao, CA, Shen, QJ. MicroRNA-134 plasma levels before and after treatment for bipolar mania. J Psychiatr Res. 2011; 45: 92-95 [OpenAIRE] [PubMed]

Forstner, AJ, Hofmann, A, Maaser, A, Sumer, S, Khudayberdiev, S, Mühleisen, TW, Leber, M, Schulze, TG, Strohmaier, J, Degenhardt, F, Treutlein, J, Mattheisen, M, Schumacher, J, Breuer, R, Meier, S, Herms, S, Hoffmann, P, Lacour, A, Witt, SH, Reif, A, Müller-Myhsok, B, Lucae, S, Maier, W, Schwarz, M, Vedder, H, Kammerer-Ciernioch, J, Pfennig, A, Bauer, M, Hautzinger, M, Moebus, S, Priebe, L, Sivalingam, S, Verhaert, A, Schulz, H, Czerski, PM, Hauser, J, Lissowska, J, Szeszenia-Dabrowska, N, Brennan, P, McKay, JD, Wright, A, Mitchell, PB, Fullerton, JM, Schofield, PR, Montgomery, GW, Medland, SE, Gordon, SD, Martin, NG, Krasnov, V, Chuchalin, A, Babadjanova, G, Pantelejeva, G, Abramova, LI, Tiganov, AS, Polonikov, A, Khusnutdinova, E, Alda, M, Cruceanu, C, Rouleau, GA, Turecki, G, Laprise, C, Rivas, F, Mayoral, F, Kogevinas, M, Grigoroiu-Serbanescu, M, Propping, P, Becker, T, Rietschel, M, Cichon, S, Schratt, G, Nöthen, MM. Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder. Transl Psychiatry. 2015; 5: e678 [OpenAIRE] [PubMed]

51 references, page 1 of 4
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publication . Article . 2016

Bipolar Disorder Associated microRNA, miR-1908-5p, Regulates the Expression of Genes Functioning in Neuronal Glutamatergic Synapses

Kim, Yoonhee; Zhang, Yinhua; Pang, Kaifang; Kang, Hyojin; Park, Heejoo; Lee, Yeunkum; Lee, Bokyoung; Lee, Heon-Jeong; Kim, Won-Ki; Geum, Dongho; ...