publication . Article . 2016

Multipronged regulatory functions of a novel endonuclease (TieA) from Helicobacter pylori

Savita Devi; Suhail A. Ansari; Shivendra Tenguria; Naveen Kumar; Niyaz Ahmed;
Open Access English
  • Published: 01 Aug 2016 Journal: Nucleic Acids Research, volume 44, issue 19, pages 9,393-9,412 (issn: 0305-1048, eissn: 1362-4962, Copyright policy)
  • Publisher: Oxford University Press
Abstract
Helicobacter pylori portrays a classical paradigm of persistent bacterial infections. A well balanced homeostasis of bacterial effector functions and host responses is purported to be the key in achieving long term colonization in specific hosts. H. pylori nucleases have been shown to assist in natural transformation, but their role in virulence and colonization remains elusive. Therefore, it is imperative to understand the involvement of these nucleases in the pathogenesis of H. pylori. Here, we report the multifaceted role of a TNFR-1 interacting endonuclease A (TieA) from H. pylori. tieA expression is differentially regulated in response to environmental stre...
Subjects
free text keywords: Nucleic Acid Enzymes, Genetics, Kinase, Transcription factor, Microbiology, Virulence, Secretion, Biology, MAPK/ERK pathway, Helicobacter pylori, biology.organism_classification, Effector, Cytokine secretion
Related Organizations
67 references, page 1 of 5

Watanabe, T., Tada, M., Nagai, H., Sasaki, S., Nakao, M.. Helicobacter pylori infection induces gastric cancer in mongolian gerbils. Gastroenterology. 1998; 115: 642-648 [PubMed]

de Martel, C., Ferlay, J., Franceschi, S., Vignat, J., Bray, F., Forman, D., Plummer, M.. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet. Oncol.. 2012; 13: 607-615 [PubMed]

Linz, B., Balloux, F., Moodley, Y., Manica, A., Liu, H., Roumagnac, P., Falush, D., Stamer, C., Prugnolle, F., van der Merwe, S.W.. An African origin for the intimate association between humans and Helicobacter pylori. Nature. 2007; 445: 915-918 [OpenAIRE] [PubMed]

Amieva, M.R., El-Omar, E.M.. Host-bacterial interactions in Helicobacter pylori infection. Gastroenterology. 2008; 134: 306-323 [OpenAIRE] [PubMed]

Wroblewski, L.E., Peek, R.M., Wilson, K.T.. Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin. Microbiol. Rev.. 2010; 23: 713-739 [OpenAIRE] [PubMed]

Israel, D.A., Salama, N., Arnold, C.N., Moss, S.F., Ando, T., Wirth, H.P., Tham, K.T., Camorlinga, M., Blaser, M.J., Falkow, S.. Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses. J. Clin. Invest.. 2001; 107: 611-620 [OpenAIRE] [PubMed]

Alm, R.A., Ling, L.S., Moir, D.T., King, B.L., Brown, E.D., Doig, P.C., Smith, D.R., Noonan, B., Guild, B.C., deJonge, B.L.. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature. 1999; 397: 176-180 [PubMed]

Peek, R.M., van Doorn, L.J., Donahue, J.P., Tham, K.T., Figueiredo, C., Blaser, M.J., Miller, G.G.. Quantitative detection of Helicobacter pylori gene expression in vivo and relationship to gastric pathology. Infect. Immun.. 2000; 68: 5488-5495 [OpenAIRE] [PubMed]

Tenguria, S., Ansari, S.A., Khan, N., Ranjan, A., Devi, S., Tegtmeyer, N., Lind, J., Backert, S., Ahmed, N.. Helicobacter pylori cell translocating kinase (CtkA/JHP0940) is pro-apoptotic in mouse macrophages and acts as auto-phosphorylating tyrosine kinase. Int. J. Med. Microbiol.: IJMM. 2014; 304: 1066-1076 [PubMed]

Brandt, S., Kwok, T., Hartig, R., Konig, W., Backert, S.. NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein. Proc. Natl. Acad. Sci. U.S.A.. 2005; 102: 9300-9305 [OpenAIRE] [PubMed]

Supajatura, V., Ushio, H., Wada, A., Yahiro, K., Okumura, K., Ogawa, H., Hirayama, T., Ra, C.. Cutting edge: VacA, a vacuolating cytotoxin of Helicobacter pylori, directly activates mast cells for migration and production of proinflammatory cytokines. J. Immunol.. 2002; 168: 2603-2607 [OpenAIRE] [PubMed]

de Jonge, R., Kuipers, E.J., Langeveld, S.C., Loffeld, R.J., Stoof, J., van Vliet, A.H., Kusters, J.G.. The Helicobacter pylori plasticity region locus jhp0947-jhp0949 is associated with duodenal ulcer disease and interleukin-12 production in monocyte cells. FEMS Immunol. Med. Microbiol.. 2004; 41: 161-167 [PubMed]

Palframan, S.L., Kwok, T., Gabriel, K.. Vacuolating cytotoxin A (VacA), a key toxin for Helicobacter pylori pathogenesis. Front. Cell. Infect. Microbiol.. 2012; 2: 92 [OpenAIRE] [PubMed]

Mobley, H.L.T., Mendz, G.L., Hazell, S.L., Mobley, HLT, Mendz, GL, Hazell, SL. Helicobacter pylori: Physiology and Genetics. 2001

Furuta, Y., Namba-Fukuyo, H., Shibata, T.F., Nishiyama, T., Shigenobu, S., Suzuki, Y., Sugano, S., Hasebe, M., Kobayashi, I.. Methylome diversification through changes in DNA methyltransferase sequence specificity. PLoS Genet.. 2014; 10: e1004272 [OpenAIRE] [PubMed]

67 references, page 1 of 5
Abstract
Helicobacter pylori portrays a classical paradigm of persistent bacterial infections. A well balanced homeostasis of bacterial effector functions and host responses is purported to be the key in achieving long term colonization in specific hosts. H. pylori nucleases have been shown to assist in natural transformation, but their role in virulence and colonization remains elusive. Therefore, it is imperative to understand the involvement of these nucleases in the pathogenesis of H. pylori. Here, we report the multifaceted role of a TNFR-1 interacting endonuclease A (TieA) from H. pylori. tieA expression is differentially regulated in response to environmental stre...
Subjects
free text keywords: Nucleic Acid Enzymes, Genetics, Kinase, Transcription factor, Microbiology, Virulence, Secretion, Biology, MAPK/ERK pathway, Helicobacter pylori, biology.organism_classification, Effector, Cytokine secretion
Related Organizations
67 references, page 1 of 5

Watanabe, T., Tada, M., Nagai, H., Sasaki, S., Nakao, M.. Helicobacter pylori infection induces gastric cancer in mongolian gerbils. Gastroenterology. 1998; 115: 642-648 [PubMed]

de Martel, C., Ferlay, J., Franceschi, S., Vignat, J., Bray, F., Forman, D., Plummer, M.. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet. Oncol.. 2012; 13: 607-615 [PubMed]

Linz, B., Balloux, F., Moodley, Y., Manica, A., Liu, H., Roumagnac, P., Falush, D., Stamer, C., Prugnolle, F., van der Merwe, S.W.. An African origin for the intimate association between humans and Helicobacter pylori. Nature. 2007; 445: 915-918 [OpenAIRE] [PubMed]

Amieva, M.R., El-Omar, E.M.. Host-bacterial interactions in Helicobacter pylori infection. Gastroenterology. 2008; 134: 306-323 [OpenAIRE] [PubMed]

Wroblewski, L.E., Peek, R.M., Wilson, K.T.. Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin. Microbiol. Rev.. 2010; 23: 713-739 [OpenAIRE] [PubMed]

Israel, D.A., Salama, N., Arnold, C.N., Moss, S.F., Ando, T., Wirth, H.P., Tham, K.T., Camorlinga, M., Blaser, M.J., Falkow, S.. Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses. J. Clin. Invest.. 2001; 107: 611-620 [OpenAIRE] [PubMed]

Alm, R.A., Ling, L.S., Moir, D.T., King, B.L., Brown, E.D., Doig, P.C., Smith, D.R., Noonan, B., Guild, B.C., deJonge, B.L.. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature. 1999; 397: 176-180 [PubMed]

Peek, R.M., van Doorn, L.J., Donahue, J.P., Tham, K.T., Figueiredo, C., Blaser, M.J., Miller, G.G.. Quantitative detection of Helicobacter pylori gene expression in vivo and relationship to gastric pathology. Infect. Immun.. 2000; 68: 5488-5495 [OpenAIRE] [PubMed]

Tenguria, S., Ansari, S.A., Khan, N., Ranjan, A., Devi, S., Tegtmeyer, N., Lind, J., Backert, S., Ahmed, N.. Helicobacter pylori cell translocating kinase (CtkA/JHP0940) is pro-apoptotic in mouse macrophages and acts as auto-phosphorylating tyrosine kinase. Int. J. Med. Microbiol.: IJMM. 2014; 304: 1066-1076 [PubMed]

Brandt, S., Kwok, T., Hartig, R., Konig, W., Backert, S.. NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein. Proc. Natl. Acad. Sci. U.S.A.. 2005; 102: 9300-9305 [OpenAIRE] [PubMed]

Supajatura, V., Ushio, H., Wada, A., Yahiro, K., Okumura, K., Ogawa, H., Hirayama, T., Ra, C.. Cutting edge: VacA, a vacuolating cytotoxin of Helicobacter pylori, directly activates mast cells for migration and production of proinflammatory cytokines. J. Immunol.. 2002; 168: 2603-2607 [OpenAIRE] [PubMed]

de Jonge, R., Kuipers, E.J., Langeveld, S.C., Loffeld, R.J., Stoof, J., van Vliet, A.H., Kusters, J.G.. The Helicobacter pylori plasticity region locus jhp0947-jhp0949 is associated with duodenal ulcer disease and interleukin-12 production in monocyte cells. FEMS Immunol. Med. Microbiol.. 2004; 41: 161-167 [PubMed]

Palframan, S.L., Kwok, T., Gabriel, K.. Vacuolating cytotoxin A (VacA), a key toxin for Helicobacter pylori pathogenesis. Front. Cell. Infect. Microbiol.. 2012; 2: 92 [OpenAIRE] [PubMed]

Mobley, H.L.T., Mendz, G.L., Hazell, S.L., Mobley, HLT, Mendz, GL, Hazell, SL. Helicobacter pylori: Physiology and Genetics. 2001

Furuta, Y., Namba-Fukuyo, H., Shibata, T.F., Nishiyama, T., Shigenobu, S., Suzuki, Y., Sugano, S., Hasebe, M., Kobayashi, I.. Methylome diversification through changes in DNA methyltransferase sequence specificity. PLoS Genet.. 2014; 10: e1004272 [OpenAIRE] [PubMed]

67 references, page 1 of 5
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publication . Article . 2016

Multipronged regulatory functions of a novel endonuclease (TieA) from Helicobacter pylori

Savita Devi; Suhail A. Ansari; Shivendra Tenguria; Naveen Kumar; Niyaz Ahmed;