PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response

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Ferrari, Elisa; Bruhn, Christopher; Peretti, Marta; Cassani, Corinne; Carotenuto, Walter Vincenzo; Elgendy, Mohamed; Shubassi, Ghadeer; Lucca, Chiara; Bermejo, Rodrigo; Varasi, Mario; Minucci, Saverio; Longhese, Maria Pia; Foiani, Marco;

(2017)

Publisher: Cell Press

Journal: Molecular Cell,volume 67,issue 2,pages266-2,810,000 (issn: 1097-2765, eissn: 1097-4164)

Publisher copyright policies & self-archiving

Related identifiers: doi: 10.1016/j.molcel.2017.05.027, pmc: PMC5526790
Subject: genome stability | TORC1 | Mec1-ATR | Irc21 | protein phosphatase PP2A | Rad53 | DNA damage response | metabolism | Article
mesheuropmc: body regions | environment and public health

Summary Mec1ATR mediates the DNA damage response (DDR), integrating chromosomal signals and mechanical stimuli. We show that the PP2A phosphatases, ceramide-activated enzymes, couple cell metabolism with the DDR. Using genomic screens, metabolic analysis, and genetic an... View more

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