PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response

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Ferrari, Elisa; Bruhn, Christopher; Peretti, Marta; Cassani, Corinne; Carotenuto, Walter Vincenzo; Elgendy, Mohamed; Shubassi, Ghadeer; Lucca, Chiara; Bermejo, Rodrigo; Varasi, Mario; Minucci, Saverio; Longhese, Maria Pia; Foiani, Marco;

Summary Mec1ATR mediates the DNA damage response (DDR), integrating chromosomal signals and mechanical stimuli. We show that the PP2A phosphatases, ceramide-activated enzymes, couple cell metabolism with the DDR. Using genomic screens, metabolic analysis, and genetic an... View more
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