Vitamin B12 as a carrier of peptide nucleic acid (PNA) into bacterial cells

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Równicki, Marcin; Wojciechowska, Monika; Wierzba, Aleksandra J.; Czarnecki, Jakub; Bartosik, Dariusz; Gryko, Dorota; Trylska, Joanna;

Short modified oligonucleotides targeted at bacterial DNA or RNA could serve as antibacterial agents provided that they are efficiently taken up by bacterial cells. However, the uptake of such oligonucleotides is hindered by the bacterial cell wall. To overcome this pro... View more
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