Modulation of nuclear REST by alternative splicing: a potential therapeutic target for Huntington's disease

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Chen, Guo‐Lin; Ma, Qi; Goswami, Dharmendra; Shang, Jianyu; Miller, Gregory M.;
  • Publisher: John Wiley and Sons Inc.
  • Journal: Journal of Cellular and Molecular Medicine,volume 21,issue 11,pages2,974-2,984 (issn: 1582-1838, eissn: 1582-4934)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1111/jcmm.13209, pmc: PMC5661251
  • Subject: Original Article | alternative splicing | nuclear translocation | Original Articles | Huntington's disease | Syn‐1 | gene therapy | REST/NRSF | antisense oligos | Stmn2 | PPARγ

Abstract Huntington's disease (HD) is caused by a genetically mutated huntingtin (mHtt) protein with expanded polyQ stretch, which impairs cytosolic sequestration of the repressor element‐1 silencing transcription factor (REST), resulting in excessive nuclear REST and s... View more