Modulation of nuclear REST by alternative splicing: a potential therapeutic target for Huntington's disease
Miller, Gregory M.
- Publisher: John Wiley and Sons Inc.
Journal of Cellular and Molecular Medicine,
(issn: 1582-1838, eissn: 1582-4934)
Original Article | alternative splicing | nuclear translocation | Original Articles | Huntington's disease | Syn‐1 | gene therapy | REST/NRSF | antisense oligos | Stmn2 | PPARγ
Abstract Huntington's disease (HD) is caused by a genetically mutated huntingtin (mHtt) protein with expanded polyQ stretch, which impairs cytosolic sequestration of the repressor element‐1 silencing transcription factor (REST), resulting in excessive nuclear REST and s...