publication . Other literature type . 2001

Several E4 Region Functions Influence Mammary Tumorigenesis by Human Adenovirus Type 9

Thomas, Darby L.; Schaack, Jerome; Vogel, Hannes; Javier, Ronald;
Open Access English
  • Published: 01 Jan 2001
  • Publisher: American Society for Microbiology
Among oncogenic adenoviruses, human adenovirus type 9 (Ad9) is unique in eliciting exclusively estrogen-dependent mammary tumors in rats and in not requiring viral E1 region transforming genes for tumorigenicity. Instead, studies with hybrid viruses generated between Ad9 and the closely related nontumorigenic virus Ad26 have roughly localized an Ad9 oncogenic determinant(s) to a segment of the viral E4 region containing open reading frame 1 (E4-ORF1), E4-ORF2, and part of E4-ORF3. Although subsequent findings have shown that E4-ORF1 codes for an oncoprotein essential for tumorigenesis by Ad9, it is not known whether other E4 region functions may similarly play a...
mesheuropmc: viruses
free text keywords: Transformation and Oncogenesis
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