publication . Article . Other literature type . 2015

Epithelial Subpopulations in NOD/ShiLtJ Mouse

GERVAIS, ELISE M.; DESANTIS, KARA A.; PAGENDARM, NICHOLAS; NELSON, DEIRDRE A.; ENGER, TONE; SKARSTEIN, KATHRINE; JENSEN, JANICKE LIAAEN; LARSEN, MELINDA;
Open Access
  • Published: 16 Jul 2015 Journal: The Anatomical Record, volume 298, pages 1,622-1,634 (issn: 1932-8486, Copyright policy)
  • Publisher: Wiley
Abstract
Sjögren’s syndrome (SS), an autoimmune exocrinopathy, is associated with dysfunction of the secretory salivary gland epithelium, leading to xerostomia. The etiology of SS disease progression is poorly understood as it is typically not diagnosed until late stage. Since mouse models allow the study of disease progression, we investigated the NOD/ShiLtJ mouse to explore temporal changes to the salivary epithelium. In the NOD/ShiLtJ model, SS presents secondary to autoimmune diabetes, and SS disease is reportedly fully established by 20 weeks. We compared epithelial morphology in the submandibular salivary glands (SMG) of NOD/ShiLtJ mice with SMGs from the parental ...
Subjects
Medical Subject Headings: stomatognathic system
free text keywords: Cytokeratin, Salivary gland, medicine.anatomical_structure, medicine, Submandibular gland, Keratin 5, Pathology, medicine.medical_specialty, Epithelium, Nod, Biology, Myoepithelial cell, Endocrinology, Population, education.field_of_study, education, Internal medicine, Article
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publication . Article . Other literature type . 2015

Epithelial Subpopulations in NOD/ShiLtJ Mouse

GERVAIS, ELISE M.; DESANTIS, KARA A.; PAGENDARM, NICHOLAS; NELSON, DEIRDRE A.; ENGER, TONE; SKARSTEIN, KATHRINE; JENSEN, JANICKE LIAAEN; LARSEN, MELINDA;