publication . Article . 2017

Genetic variations of NTCP are associated with susceptibility to HBV infection and related hepatocellular carcinoma

Peng Wang; Ruidong Mo; Rongtao Lai; Yumin Xu; Jie Lu; Gangde Zhao; Yuhan Liu; Zhujun Cao; Xiaolin Wang; Ziqiang Li; ...
Open Access English
  • Published: 31 Oct 2017 Journal: Oncotarget, volume 8, issue 62, pages 105,407-105,424 (eissn: 1949-2553, Copyright policy)
  • Publisher: Impact Journals LLC
Abstract
// Peng Wang 1, 2, * , Ruidong Mo 1, 2, * , Rongtao Lai 1, 2, * , Yumin Xu 1, 2 , Jie Lu 2 , Gangde Zhao 1, 2 , Yuhan Liu 1, 2 , Zhujun Cao 1, 2 , Xiaolin Wang 1, 2 , Ziqiang Li 1, 2 , Lanyi Lin 1 , Huijuan Zhou 1 , Wei Cai 1 , Hui Wang 1 , Shisan Bao 1, 3 , Xiaogang Xiang 1, 2 and Qing Xie 1, 2 1 Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China 2 Translational Lab of Liver Diseases, Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China 3 Discipline of Pathology, School of Medical Sciences and Bosch Institute, The University of Sydne...
Subjects
free text keywords: Research Paper, Na+ taurocholate cotransporting polypeptide, association study, HBV, HCC, meta-analysis, Oncology, Hepatitis B, medicine.disease, medicine, Hepatocellular carcinoma, business.industry, business, Gastroenterology, medicine.medical_specialty, Single-nucleotide polymorphism, Genetic variation, SLC10A1, biology.protein, biology, Immunology, Cirrhosis, Hepatitis B virus, medicine.disease_cause, Internal medicine, Dominance (genetics)
50 references, page 1 of 4

Trepo, C, Chan, HL, Lok, A. Hepatitis B virus infection. Lancet. 2014; 384: 2053-2063 [OpenAIRE] [PubMed]

Liang, X, Bi, S, Yang, W, Wang, L, Cui, G, Cui, F, Zhang, Y, Liu, J, Gong, X, Chen, Y, Wang, F, Zheng, H, Wang, F. Epidemiological serosurvey of hepatitis B in China--declining HBV prevalence due to hepatitis B vaccination. Vaccine. 2009; 27: 6550-6557 [PubMed]

Cui, Y, Jia, J. Update on epidemiology of hepatitis B and C in China. J Gastroenterol Hepatol. 2013; 28: 7-10

Beasley, RP, Hwang, LY, Lin, CC, Chien, CS. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet. 1981; 2: 1129-1133 [OpenAIRE] [PubMed]

Lee, MH, Yang, HI, Liu, J, Batrla-Utermann, R, Jen, CL, Iloeje, UH, Lu, SN, You, SL, Wang, LY, Chen, CJ. Prediction models of long-term cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: risk scores integrating host and virus profiles. Hepatology. 2013; 58: 546-554 [PubMed]

Yan, H, Zhong, G, Xu, G, He, W, Jing, Z, Gao, Z, Huang, Y, Qi, Y, Peng, B, Wang, H, Fu, L, Song, M, Chen, P. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. eLife. 2012; 1: e00049 [OpenAIRE] [PubMed]

Stieger, B, Hagenbuch, B, Landmann, L, Hochli, M, Schroeder, A, Meier, PJ. In situ localization of the hepatocytic Na+/Taurocholate cotransporting polypeptide in rat liver. Gastroenterology. 1994; 107: 1781-1787 [OpenAIRE] [PubMed]

Tiollais, P, Pourcel, C, Dejean, A. The hepatitis B virus. Nature. 1985; 317: 489-495 [OpenAIRE] [PubMed]

Kang, J, Wang, J, Cheng, J, Cao, Z, Chen, R, Li, H, Liu, S, Chen, X, Sui, J, Lu, F. Down-regulation of NTCP expression by cyclin D1 in hepatitis B virus-related hepatocellular carcinoma has clinical significance. Oncotarget. 2016; 8: 56041-56050 [OpenAIRE] [PubMed]

Peng, L, Zhao, Q, Li, Q, Li, M, Li, C, Xu, T, Jing, X, Zhu, X, Wang, Y, Li, F, Liu, R, Zhong, C, Pan, Q. The p.Ser267Phe variant in SLC10A1 is associated with resistance to chronic hepatitis. B. Hepatology. 2014; 61: 1251-1260

Li, N, Zhang, P, Yang, C, Zhu, Q, Li, Z, Li, F, Han, Q, Wang, Y, Lv, Y, Wei, P, Liu, Z. Association of genetic variation of sodium taurocholate cotransporting polypeptide with chronic hepatitis B virus infection. Genet Test Mol Biomarkers. 2014; 18: 425-429 [OpenAIRE] [PubMed]

Hu, HH, Liu, J, Lin, YL, Luo, WS, Chu, YJ, Chang, CL, Jen, CL, Lee, MH, Lu, SN, Wang, LY, You, SL, Yang, HI, Chen, CJ. The rs2296651 (S267F) variant on NTCP (SLC10A1) is inversely associated with chronic hepatitis B and progression to cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis B. Gut. 2015

Yang, J, Yang, Y, Xia, M, Wang, L, Zhou, W, Jiang, Y, Wang, H, Qian, J, Jin, L, Wang, X. A genetic variant of the NTCP gene is associated with HBV infection status in a Chinese population. BMC Cancer. 2016; 16: 211 [OpenAIRE] [PubMed]

Zhang, Y, Li, Y, Wu, M, Cao, P, Liu, X, Ren, Q, Zhai, Y, Xie, B, Hu, Y, Hu, Z, Bei, J, Ping, J, Liu, X. Comprehensive assessment showed no associations of variants at the SLC10A1 locus with susceptibility to persistent HBV infection among Southern Chinese. Sci Rep. 2017; 7: 46490 [OpenAIRE] [PubMed]

Stroffolini, T, Esvan, R, Biliotti, E, Sagnelli, E, Gaeta, GB, Almasio, PL. Gender differences in chronic HBsAg carriers in Italy: evidence for the independent role of male sex in severity of liver disease. J Med Virol. 2015; 87: 1899-1903 [OpenAIRE] [PubMed]

50 references, page 1 of 4
Abstract
// Peng Wang 1, 2, * , Ruidong Mo 1, 2, * , Rongtao Lai 1, 2, * , Yumin Xu 1, 2 , Jie Lu 2 , Gangde Zhao 1, 2 , Yuhan Liu 1, 2 , Zhujun Cao 1, 2 , Xiaolin Wang 1, 2 , Ziqiang Li 1, 2 , Lanyi Lin 1 , Huijuan Zhou 1 , Wei Cai 1 , Hui Wang 1 , Shisan Bao 1, 3 , Xiaogang Xiang 1, 2 and Qing Xie 1, 2 1 Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China 2 Translational Lab of Liver Diseases, Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China 3 Discipline of Pathology, School of Medical Sciences and Bosch Institute, The University of Sydne...
Subjects
free text keywords: Research Paper, Na+ taurocholate cotransporting polypeptide, association study, HBV, HCC, meta-analysis, Oncology, Hepatitis B, medicine.disease, medicine, Hepatocellular carcinoma, business.industry, business, Gastroenterology, medicine.medical_specialty, Single-nucleotide polymorphism, Genetic variation, SLC10A1, biology.protein, biology, Immunology, Cirrhosis, Hepatitis B virus, medicine.disease_cause, Internal medicine, Dominance (genetics)
50 references, page 1 of 4

Trepo, C, Chan, HL, Lok, A. Hepatitis B virus infection. Lancet. 2014; 384: 2053-2063 [OpenAIRE] [PubMed]

Liang, X, Bi, S, Yang, W, Wang, L, Cui, G, Cui, F, Zhang, Y, Liu, J, Gong, X, Chen, Y, Wang, F, Zheng, H, Wang, F. Epidemiological serosurvey of hepatitis B in China--declining HBV prevalence due to hepatitis B vaccination. Vaccine. 2009; 27: 6550-6557 [PubMed]

Cui, Y, Jia, J. Update on epidemiology of hepatitis B and C in China. J Gastroenterol Hepatol. 2013; 28: 7-10

Beasley, RP, Hwang, LY, Lin, CC, Chien, CS. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet. 1981; 2: 1129-1133 [OpenAIRE] [PubMed]

Lee, MH, Yang, HI, Liu, J, Batrla-Utermann, R, Jen, CL, Iloeje, UH, Lu, SN, You, SL, Wang, LY, Chen, CJ. Prediction models of long-term cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: risk scores integrating host and virus profiles. Hepatology. 2013; 58: 546-554 [PubMed]

Yan, H, Zhong, G, Xu, G, He, W, Jing, Z, Gao, Z, Huang, Y, Qi, Y, Peng, B, Wang, H, Fu, L, Song, M, Chen, P. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. eLife. 2012; 1: e00049 [OpenAIRE] [PubMed]

Stieger, B, Hagenbuch, B, Landmann, L, Hochli, M, Schroeder, A, Meier, PJ. In situ localization of the hepatocytic Na+/Taurocholate cotransporting polypeptide in rat liver. Gastroenterology. 1994; 107: 1781-1787 [OpenAIRE] [PubMed]

Tiollais, P, Pourcel, C, Dejean, A. The hepatitis B virus. Nature. 1985; 317: 489-495 [OpenAIRE] [PubMed]

Kang, J, Wang, J, Cheng, J, Cao, Z, Chen, R, Li, H, Liu, S, Chen, X, Sui, J, Lu, F. Down-regulation of NTCP expression by cyclin D1 in hepatitis B virus-related hepatocellular carcinoma has clinical significance. Oncotarget. 2016; 8: 56041-56050 [OpenAIRE] [PubMed]

Peng, L, Zhao, Q, Li, Q, Li, M, Li, C, Xu, T, Jing, X, Zhu, X, Wang, Y, Li, F, Liu, R, Zhong, C, Pan, Q. The p.Ser267Phe variant in SLC10A1 is associated with resistance to chronic hepatitis. B. Hepatology. 2014; 61: 1251-1260

Li, N, Zhang, P, Yang, C, Zhu, Q, Li, Z, Li, F, Han, Q, Wang, Y, Lv, Y, Wei, P, Liu, Z. Association of genetic variation of sodium taurocholate cotransporting polypeptide with chronic hepatitis B virus infection. Genet Test Mol Biomarkers. 2014; 18: 425-429 [OpenAIRE] [PubMed]

Hu, HH, Liu, J, Lin, YL, Luo, WS, Chu, YJ, Chang, CL, Jen, CL, Lee, MH, Lu, SN, Wang, LY, You, SL, Yang, HI, Chen, CJ. The rs2296651 (S267F) variant on NTCP (SLC10A1) is inversely associated with chronic hepatitis B and progression to cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis B. Gut. 2015

Yang, J, Yang, Y, Xia, M, Wang, L, Zhou, W, Jiang, Y, Wang, H, Qian, J, Jin, L, Wang, X. A genetic variant of the NTCP gene is associated with HBV infection status in a Chinese population. BMC Cancer. 2016; 16: 211 [OpenAIRE] [PubMed]

Zhang, Y, Li, Y, Wu, M, Cao, P, Liu, X, Ren, Q, Zhai, Y, Xie, B, Hu, Y, Hu, Z, Bei, J, Ping, J, Liu, X. Comprehensive assessment showed no associations of variants at the SLC10A1 locus with susceptibility to persistent HBV infection among Southern Chinese. Sci Rep. 2017; 7: 46490 [OpenAIRE] [PubMed]

Stroffolini, T, Esvan, R, Biliotti, E, Sagnelli, E, Gaeta, GB, Almasio, PL. Gender differences in chronic HBsAg carriers in Italy: evidence for the independent role of male sex in severity of liver disease. J Med Virol. 2015; 87: 1899-1903 [OpenAIRE] [PubMed]

50 references, page 1 of 4
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