The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo

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Lucas, David M.; Edwards, Ryan B.; Lozanski, Gerard; West, Derek A.; Shin, Jungook D.; Vargo, Melissa A.; Davis, Melanie E.; Rozewski, Darlene M.; Johnson, Amy J.; Su, Bao-Ning; Goettl, Virginia M.; Heerema, Nyla A.; Lin, Thomas S.; Lehman, Amy; Zhang, Xiaoli; Jarjoura, David; Newman, David J.; Byrd, John C.; Kinghorn, A. Douglas; Grever, Michael R.;

Therapeutic options for advanced B-cell acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL) are limited. Available treatments can also deplete T lymphocytes, leaving patients at risk of life-threatening infections. In the National Cancer Institute ... View more
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