publication . Article . Other literature type . 2016

Increased Expression of mir-34a-5p and Clinical Association in Acute Ischemic Stroke Patients and in a Rat Model

Liang, Ting-ying; Lou, Ji-yu;
Open Access
  • Published: 22 Aug 2016 Journal: Medical Science Monitor, volume 22, pages 2,950-2,955 (eissn: 1643-3750, Copyright policy)
  • Publisher: International Scientific Information, Inc.
Background MiRNA is widely recognized as the most important regulator in various diseases. However, there has been little research regarding miRNA expression and its involvement in ischemic stroke. Material/Methods In this study, we investigated the pattern of miRNA-34a-5p expression along with its clinical application in human ischemic stroke and in an in vivo rat model. We recruited 102 cerebral ischemia patients and 97 health controls for this study. Clinical data were gathered and recorded with the help of questionnaires. Blood samples were obtained from patients within 72 h after cerebral ischemia. National Institutes of Health Stroke Scale (NIHSS), Acute S...
Medical Subject Headings: cardiovascular diseases
free text keywords: Stroke, medicine.disease, medicine, Acute ischemic stroke, Regulator, Diabetes mellitus, Bioinformatics, microRNA, Internal medicine, medicine.medical_specialty, Endocrinology, business.industry, business, Brain ischemia, Mirna expression, Physical therapy, Animal Study, MicroRNAs
Related Organizations
26 references, page 1 of 2

Low, SY, Ho, YK, Too, HP. MicroRNA as potential modulators in chemoresistant high-grade gliomas. J Clin Neurosci. 2014; 21: 395-400 [PubMed]

Jeyaseelan, K, Lim, KY, Armugam, A. MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion. Stroke. 2008; 39: 959-66 [OpenAIRE] [PubMed]

Ouyang, YB, Stary, CM, Yang, GY. microRNAs: Innovative targets for cerebral ischemia and stroke. Curr Drug Targets. 2013; 14: 90-101 [OpenAIRE] [PubMed]

Liu, XS, Michael, C, Zhang, RL. MicroRNAs in cerebral ischemia-induced neurogenesis. J Neuropathol Exp Neurol. 2013; 72: 718-22 [OpenAIRE] [PubMed]

Rink, C, Khanna, S. MicroRNA in ischemic stroke etiology and pathology. Physiological Genomics. 2011; 43: 521-28 [OpenAIRE] [PubMed]

Dharap, A, Bowen, K, Place, R. Transient focal ischemia induces extensive temporal changes in rat cerebral MicroRNAome. J Cereb Blood Flow Metab. 2009; 29: 675-87 [OpenAIRE] [PubMed]

Sepramaniam, S, Armugam, A, Lim, KY. MicroRNA 320a functions as a novel endogenous modulator of aquaporins 1 and 4 as well as a potential therapeutic target in cerebral ischemia. J Bio Chem. 2010; 285: 29223-30 [OpenAIRE] [PubMed]

Tan, KS, Armugam, A, Sepramaniam, S. Expression profile of microRNAs in young stroke patients. PLoS One. 2009; 4: e7689 [OpenAIRE] [PubMed]

Agostini, M, Tucci, P, Steinert, JR. microRNA-34a regulates neurite outgrowth, spinal morphology, and function. Proc Natl Acad Sci USA. 2011; 108: 21099-104 [OpenAIRE] [PubMed]

Special report from the National Institute of Neurological Disorders and Stroke: Classification of cerebrovascular diseases III. Stroke. 1990; 21: 637-76 [PubMed]

Adams, HP, Bendixen, BH, Kappelle, LJ. Classification of subtype of acute ischemic stroke Definitions for use in a multicenter clinical trial TOAST Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993; 24: 35-41 [PubMed]

Sims, JR, Gharai, LR, Schaefer, PW. ABC/2 for rapid clinical estimate of infarct, perfusion, and mismatch volumes. Neurology. 2009; 72: 2104-10 [OpenAIRE] [PubMed]

Whiteley, W, Tian, Y, Jickling, GC. Blood biomarkers in stroke: Research and clinical practice. Int J Stroke. 2012; 7: 435-39 [PubMed]

Jickling, GC, Sharp, FR. Blood biomarkers of ischemic stroke. Neurotherapeutics. 2011; 8: 349-60 [OpenAIRE] [PubMed]

Zhao, D, Bi, G, Feng, J. Association of serum chemerin levels with acute ischemic stroke and carotid artery atherosclerosis in a Chinese population. Med Sci Monit. 2015; 21: 3121-28 [OpenAIRE] [PubMed]

26 references, page 1 of 2
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . Other literature type . 2016

Increased Expression of mir-34a-5p and Clinical Association in Acute Ischemic Stroke Patients and in a Rat Model

Liang, Ting-ying; Lou, Ji-yu;