publication . Other literature type . Article . 2018

Effect of NXY‐059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window

Sydserff, S G; Borelli, A R; Green, A R; Cross, A J;
  • Published: 13 Nov 2018
  • Publisher: Wiley
Abstract
The efficacy of the free radical trapping agent NXY-059 in reducing the infarct volume following both transient and permanent focal ischaemia has been examined in rats. In the transient ischaemia model, rats were subjected to a 2 h occlusion of the middle cerebral artery (MCA). Intravenous infusion of NXY-059 (1, 10 and 30 mg kg−1 h) for 21.75 h starting 2.25 h after the occlusion, produced a dose-dependent decrease in both neurological impairment and the histologically measured infarct volume (a mean 59% decrease at 10 mg kg−1 h). In the permanent ischaemia model, animals were injected (s.c.) with a loading dose of NXY-059 of 32.5, 53.8 or 75.4 mg kg−1 and osmo...
Subjects
free text keywords: Pharmacology, Loading dose, Brain ischemia, medicine.disease, medicine, Ischemia, Anesthesia, Stroke, Cerebral infarction, Occlusion, Middle cerebral artery, medicine.artery, Cerebral arteries, business.industry, business, Papers
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publication . Other literature type . Article . 2018

Effect of NXY‐059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window

Sydserff, S G; Borelli, A R; Green, A R; Cross, A J;