publication . Other literature type . 1989

Recognition of xeno-(HLA, SLA) major histocompatibility complex antigens by mouse cytotoxic T cells is not H-2 restricted: a study with transgenic mice.

Kievits, F; Wijffels, J; Lokhorst, W; Ivanyi, P;
Open Access English
  • Published: 01 Jan 1989
Abstract
Cytotoxic T lymphocytes (CTLs) recognize antigens in the context of major histocompatibility complex (MHC) class I gene products. The T-cell receptor (TCR) that mediates this MHC-restricted antigen recognition recognizes short peptide fragments rather than the intact antigen. Presentation of peptides to the TCR may thus be a major function of the MHC. An intriguing question emerging from this model is whether peptide presentation also applies to foreign MHC antigens and which of the available MHC molecules can present preferentially the peptides of the foreign MHC molecule. Allo- and xenoreactive CTLs might either recognize native MHC class I molecules or peptid...
Subjects
mesheuropmc: chemical and pharmacologic phenomena
free text keywords: Research Article
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Other literature type . 1989
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