publication . Other literature type . Article . 2011

Emerging Theme: Cellular PDZ Proteins as Common Targets of Pathogenic Viruses

R. T. Javier; A. P. Rice;
Open Access English
  • Published: 20 Jul 2011
  • Publisher: American Society for Microbiology
Abstract
ABSTRACT More than a decade ago, three viral oncoproteins, adenovirus type 9 E4-ORF1, human T-lymphotropic virus type 1 Tax, and high-risk human papillomavirus E6, were found to encode a related carboxyl-terminal PDZ domain-binding motif (PBM) that mediates interactions with a select group of cellular PDZ proteins. Recent studies have shown that many other viruses also encode PBM-containing proteins that bind to cellular PDZ proteins. Interestingly, these recently recognized viruses include not only some with oncogenic potential (hepatitis B virus, rhesus papillomavirus, cottontail rabbit papillomavirus) but also many without this potential (influenza virus, Den...
Subjects
Medical Subject Headings: viruses
free text keywords: Minireview, Immunology, Insect Science, Microbiology, Virology, Rabies virus, medicine.disease_cause, medicine, Protein family, Virus classification, Plasma protein binding, Biology, Virus, Dengue virus, Molecular biology, PDZ domain, DLG1, biology.protein
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publication . Other literature type . Article . 2011

Emerging Theme: Cellular PDZ Proteins as Common Targets of Pathogenic Viruses

R. T. Javier; A. P. Rice;