Enzyme-Specific Differences in Mannose Phosphorylation Between GlcNAc-1-Phosphotransferase αβ and γ subunit Deficient Zebrafish Support Cathepsin Proteases As Early Mediators of Mucolipidosis Pathology

Other literature type English OPEN
Flanagan-Steet, Heather; Matheny, Courtney; Petrey, Aaron; Parker, Joshua; Steet, Richard;

Targeting soluble acid hydrolases to lysosomes requires the addition of mannose 6-phosphate residues on their N-glycans. This process is initiated by GlcNAc-1-phosphotransferase, a multi-subunit enzyme encoded by the GNPTAB and GNPTG genes. The GNPTAB gene products (the... View more
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