Characterization of the Mechanisms of Daptomycin Resistance among Gram-Positive Bacterial Pathogens by Multidimensional Lipidomics

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Hines, Kelly M.; Waalkes, Adam; Penewit, Kelsi; Holmes, Elizabeth A.; Salipante, Stephen J.; Werth, Brian J.; Xu, Libin;
  • Publisher: American Society for Microbiology
  • Journal: mSphere,volume 2,issue 6 (eissn: 2379-5042)
  • Related identifiers: pmc: PMC5729219, doi: 10.1128/mSphere.00492-17
  • Subject: Gram-positive bacteria | PgsA | ion mobility-mass spectrometry | Research Article | Therapeutics and Prevention | antibiotic resistance | whole-genome sequencing | daptomycin | lipidomics

ABSTRACT Previous work suggests that altered lipid metabolism may be associated with daptomycin resistance in Gram-positive pathogens, but lipidomic changes underlying resistance are not fully understood. We performed untargeted lipidomics by using three-dimensional hyd... View more
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