publication . Article . Other literature type . 2018

Viral oncoprotein-induced mislocalization of select PDZ proteins disrupts tight junctions and causes polarity defects in epithelial cells

Latorre, Isabel J.; Roh, Michael H.; Frese, Kristopher K.; Weiss, Robert S.; Margolis, Ben; Javier, Ronald T.;
Open Access
  • Published: 13 Nov 2018 Journal: Journal of Cell Science, volume 118, pages 4,283-4,293 (issn: 0021-9533, eissn: 1477-9137, Copyright policy)
  • Publisher: The Company of Biologists
Abstract
The development of human cancers is frequently associated with a failure of epithelial cells to form tight junctions and to establish proper apicobasal polarity. Interestingly, the oncogenic potential of the adenovirus E4-ORF1 protein correlates with its binding to the cellular PDZ proteins MUPP1, MAGI-1, ZO-2 and SAP97, the first three of which assemble protein complexes at tight junctions. Given that E4-ORF1 sequesters these three PDZ proteins in the cytoplasm of fibroblasts, we postulated that E4-ORF1 would inhibit tight junction formation in epithelial cells. Providing further support for this idea, we identified MUPP1-related PATJ, a key component of the ti...
Subjects
free text keywords: Cell Biology, Tight junction, Membrane protein, Molecular biology, Plasma protein binding, Claudin, Cytoplasm, Cell polarity, PDZ domain, DNA-binding protein, Biology, Article
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publication . Article . Other literature type . 2018

Viral oncoprotein-induced mislocalization of select PDZ proteins disrupts tight junctions and causes polarity defects in epithelial cells

Latorre, Isabel J.; Roh, Michael H.; Frese, Kristopher K.; Weiss, Robert S.; Margolis, Ben; Javier, Ronald T.;