Viral oncoprotein-induced mislocalization of select PDZ proteins disrupts tight junctions and causes polarity defects in epithelial cells

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Latorre, Isabel J.; Roh, Michael H.; Frese, Kristopher K.; Weiss, Robert S.; Margolis, Ben; Javier, Ronald T.;

The development of human cancers is frequently associated with a failure of epithelial cells to form tight junctions and to establish proper apicobasal polarity. Interestingly, the oncogenic potential of the adenovirus E4-ORF1 protein correlates with its binding to the ... View more
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