β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Increases Amyloid Deposition in Brain Parenchyma but Reduces Cerebrovascular Amyloid Angiopathy in Aging BACE × APP[V717I] Double-Transgenic Mice

Other literature type English OPEN
Willem, Michael; Dewachter, Ilse; Smyth, Neil; Van Dooren, Tom; Borghgraef, Peter; Haass, Christian; Van Leuven, Fred;
(2004)
  • Publisher: American Society for Investigative Pathology
  • Identifiers: pmc: PMC1618675
  • Subject: Original Research Paper
    mesheuropmc: mental disorders

The generation of amyloid peptides (Aβ) from the amyloid precursor protein (APP) is initiated by β-secretase (BACE), whereas subsequent γ-secretase cleavage mediated by presenilin-1, produces Aβ peptides mainly of 40 or 42 amino acids long. In addition, alternative β′-c... View more
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