The Small Molecule Chloropyramine Hydrochloride (C4) Targets the Binding Site of Focal Adhesion Kinase and Vascular Endothelial Growth Factor Receptor 3 and Suppresses Breast Cancer Growth in vivo

Other literature type English OPEN
Kurenova, Elena V.; Hunt, Darell L.; He, Dihua; Magis, Andrew T.; Ostrov, David A.; Cance, William G.;
(2009)

FAK is a tyrosine kinase that functions as a key orchestrator of signals leading to invasion and metastasis. Since FAK interacts directly with a number of critical proteins involved in survival signaling in tumor cells, we hypothesized that targeting a key protein-prote... View more
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