publication . Article . Other literature type . 2015

Mercury Reduces the Enzymatic Activity of Neprilysin in Differentiated SH-SY5Y Cells.

Chin-Chan, Miguel; Segovia, José; Quintanar, Liliana; Arcos-López, Trinidad; Hersh, Louis B.; Chow, K. Martin; Rodgers, David W.; Quintanilla-Vega, Betzabet;
  • Published: 10 Feb 2015
  • Publisher: Oxford University Press (OUP)
Abstract
Levels of amyloid beta (Aβ) in the central nervous system are regulated by the balance between its synthesis and degradation. Neprilysin (NEP) is associated with Alzheimer’s disease (AD) by its ability to degrade Aβ. Some studies have involved the exposure to mercury (Hg) in AD pathogenesis; therefore, our aim was to investigate the effects on the anabolism and catabolism of Aβ in differentiated SH-SY5Y cells incubated with 1–20 μM of Hg. Exposure to 20 µM of Hg induced an increase in Aβ-42 secretion, but did not increase the expression of the amyloid precursor protein (APP). Hg incubation (10 and 20 µM) increased NEP protein levels; however, it did not change N...
Subjects
Medical Subject Headings: fungi
free text keywords: Toxicology, Peptide, chemistry.chemical_classification, chemistry, Amyloid beta, biology.protein, biology, Biochemistry, Amyloid precursor protein, SH-SY5Y, Catabolism, Amyloid, Neprilysin, Conformational change, Endocrinology, medicine.medical_specialty, medicine, Internal medicine, Mercury Inhibition of Metalloprotease
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publication . Article . Other literature type . 2015

Mercury Reduces the Enzymatic Activity of Neprilysin in Differentiated SH-SY5Y Cells.

Chin-Chan, Miguel; Segovia, José; Quintanar, Liliana; Arcos-López, Trinidad; Hersh, Louis B.; Chow, K. Martin; Rodgers, David W.; Quintanilla-Vega, Betzabet;