A non-catalytic function of SETD1A regulates Cyclin-K and the DNA damage response

Other literature type English OPEN
Hoshii, Takayuki; Cifani, Paolo; Feng, Zhaohui; Huang, Chun-Hao; Koche, Richard; Chen, Chun-Wei; Delaney, Christopher D.; Lowe, Scott W.; Kentsis, Alex; Armstrong, Scott A.;

MLL/SET methyltransferases catalyze methylation of histone 3 lysine 4 and play critical roles in development and cancer. We assessed MLL/SET proteins and found that SETD1A is required for survival of acute myeloid leukemia (AML) cells. Mutagenesis studies and CRISPR-Cas... View more
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