publication . Article . 2012

Prolonged oral administration of oleuropein might protect heart against aconitine-induced arrhythmia

Esmailidehaj, Mansour; Mirhosseini, Seyed-Jalil; Rezvani, Mohammad Ebrahim; Bahram Rasoulian; Hossein, Mosaddeghmehrjardi Mohammad; Haghshenas, Damoon;
  • Published: 01 Jan 2012
In this study, it was surveyed to know whether an oral single dose of oleuropein could mimic the cardiac preconditioning in rats’ hearts or whether its prolonged oral administration could protect the heart against the aconitine-induced arrhythmia in rats. Eighty male Wistar rats were divided into two series (n = 8 in each group). In the first series, all groups (except the control (Con) group) were given a single oral dose of oleuropein (20 mg/Kg) 1, 3, 24 and 48 h before the infusion of aconitine. In the second series, except the Con group, the other four groups were given oral oleuropein (20 mg/Kg/day) for 3, 7, 14 and 28 days, before the infusion of aconitine...
free text keywords: Original Article, Oleuropein, Aconitine, Rat, Ventricular fibrillation, Ventricular tachycardia, Arrhythmia
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