PennSeq: accurate isoform-specific gene expression quantification in RNA-Seq by modeling non-uniform read distribution

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Hu, Yu; Liu, Yichuan; Mao, Xianyun; Jia, Cheng; Ferguson, Jane F.; Xue, Chenyi; Reilly, Muredach P.; Li, Hongzhe; Li, Mingyao;
(2013)

Correctly estimating isoform-specific gene expression is important for understanding complicated biological mechanisms and for mapping disease susceptibility genes. However, estimating isoform-specific gene expression is challenging because various biases present in RNA... View more