Antimicrobial resistance mechanisms and potential synthetic treatments

Article English OPEN
Ali, Junaid ; Rafiq, Qasim A. ; Ratcliffe, Elizabeth (2018)
  • Publisher: Future Science Ltd
  • Journal: Future Science OA, volume 4, issue 4 (eissn: 2056-5623)
  • Related identifiers: pmc: PMC5905577, doi: 10.4155/fsoa-2017-0109
  • Subject: molecular biology | re-sensitizing | antimicrobial resistance | Review | infectious agents | antibiotics | resistance mechanisms

Since the discovery of antibiotics by Sir Alexander Fleming they have been used throughout medicine and play a vital role in combating microorganisms. However, with their vast use, development of resistance has become more prevalent and their use is currently under threat. Antibiotic resistance poses a global threat to human and animal health, with many bacterial species having developed some form of resistance and in some cases within a year of first exposure to antimicrobial agents. This review aims to examine some of the mechanisms behind resistance. Additionally, re-engineering organisms, re-sensitizing bacteria to antibiotics and gene-editing techniques such as the clustered regularly interspaced short palindromic repeats-Cas9 system are providing novel approaches to combat bacterial resistance. To that extent, we have reviewed some of these novel and innovative technologies.
Share - Bookmark