publication . Other literature type . Article . 2008

Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction

Xuesen Li; Zhongbo Liu; Cheng Luo; Haiqun Jia; Lijuan Sun; Bei Hou; Weili Shen; Lester Packer; Carl W. Cotman; Jiankang Liu;
Open Access English
  • Published: 01 Apr 2008
Abstract
α-Lipoic acid (LA) has been widely studied as an agent for preventing and treating various diseases associated with oxidative disruption of mitochondrial functions. To investigate a related mitochondrial antioxidant, we compared the effects of lipoamide (LM), the neutral amide of LA, with LA for measures of oxidative damage and mitochondrial dysfunction in a human retinal pigment epithelial (RPE) cell line. Acrolein, a major component of cigarette smoke and a product of lipid peroxidation, was used to induce oxidative mitochondrial damage in RPE cells. Overall, using comparable concentrations, LM was more effective than LA at preventing acrolein-induced mitochon...
Subjects
free text keywords: Article, Oxidative phosphorylation, Lipoamide, chemistry.chemical_compound, chemistry, Mitochondrion, Biochemistry, Superoxide dismutase, biology.protein, biology, Antioxidant, medicine.medical_treatment, medicine, Lipid peroxidation, Glutathione, Oxidative stress, medicine.disease_cause
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publication . Other literature type . Article . 2008

Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction

Xuesen Li; Zhongbo Liu; Cheng Luo; Haiqun Jia; Lijuan Sun; Bei Hou; Weili Shen; Lester Packer; Carl W. Cotman; Jiankang Liu;