publication . Other literature type . Article . 2017

Inhibition of the Mitochondrial Pyruvate Carrier by Tolylfluanid

Yana Chen; Kyle S McCommis; Daniel Ferguson; Angela M Hall; Charles A Harris; Brian N Finck;
Open Access English
  • Published: 08 Nov 2017
  • Publisher: Endocrine Society
Abstract
Several recent studies have suggested that compounds known as endocrine-disrupting chemicals (EDCs) can promote obesity by serving as ligands for nuclear receptors, including the peroxisome proliferator–activated receptor γ (PPARγ) and the glucocorticoid receptor (GR). Thiazolidinedione insulin sensitizers, which act as ligands for PPARγ, also interact with and regulate the activity of the mitochondrial pyruvate carrier (MPC). We evaluated whether several EDCs might also affect MPC activity. Most of the EDCs evaluated did not acutely affect pyruvate metabolism. However, the putative endocrine disruptors tributyltin (TBT) and tolylfluanid (TF) acutely and markedl...
Subjects
free text keywords: Research Articles, Diabetes mellitus, medicine.disease, medicine, Endocrinology, medicine.medical_specialty, Pyruvate carrier, Biology, Internal medicine
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Europe PubMed Central
Other literature type . 2017
Endocrinology
Article . 2017
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publication . Other literature type . Article . 2017

Inhibition of the Mitochondrial Pyruvate Carrier by Tolylfluanid

Yana Chen; Kyle S McCommis; Daniel Ferguson; Angela M Hall; Charles A Harris; Brian N Finck;