Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress

Other literature type English OPEN
Oravcová, Martina; Gadaleta, Mariana C.; Nie, Minghua; Reubens, Michael C.; Limbo, Oliver; Russell, Paul; Boddy, Michael N.;
(2019)

As genetic instability drives disease or loss of cell fitness, cellular safeguards have evolved to protect the genome, especially during sensitive cell cycle phases, such as DNA replication. Fission yeast Brc1 has emerged as a key factor in promoting cell survival when ... View more
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