publication . Other literature type . Article . 2010

Strong antibody responses induced by protein antigens conjugated onto the surface of lecithin-based nanoparticles.

Sloat Brian R.; Sandoval Michael A.; Hau Andrew M.; He Yongqun; Cui Zhengrong;
  • Published: 04 Jan 2010
  • Publisher: Elsevier BV
Abstract
An accumulation of research over the years has demonstrated the utility of nanoparticles as antigen carriers with adjuvant activity. Herein we defined the adjuvanticity of a novel lecithin-based nanoparticle engineered from emulsions. The nanoparticles were spheres of around 200 nm. Model protein antigens, bovine serum albumin (BSA) or Bacillus anthracis protective antigen (PA) protein, were covalently conjugated onto the nanoparticles. Mice immunized with the BSA-conjugated nanoparticles developed strong anti-BSA antibody responses comparable to that induced by BSA adjuvanted with incomplete Freund's adjuvant and 6.5-fold stronger than that induced by BSA adsor...
Subjects
free text keywords: Pharmaceutical Science, Bacillus anthracis, biology.organism_classification, biology, Bovine serum albumin, biology.protein, Molecular biology, Antibody, Lethal dose, Antigen, Adjuvant, medicine.medical_treatment, medicine, Adjuvanticity, Chemistry, Drug carrier, Article
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