Englerin A-sensing charged residues for transient receptor potential canonical 5 channel activation

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Jeong, SeungJoo; Ko, Juyeon; Kim, Minji; Park, Ki Chul; Park, Eunice Yon June; Kim, Jinsung; Baik, Youngjoo; Wie, Jinhong; Cho, Art E.; Jeon, Ju-hong; So, Insuk;
  • Publisher: The Korean Physiological Society and The Korean Society of Pharmacology
  • Journal: The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, volume 23, issue 3, pages 191-201 (issn: 1226-4512, eissn: 2093-3827)
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  • Related identifiers: pmc: PMC6488704, doi: 10.4196/kjpp.2019.23.3.191
  • Subject: Original Article | Englerin A | Ion channels | Mutant proteins | Transient receptor potential canonical 5

The transient receptor potential canonical (TRPC) 5 channel, known as a nonselective cation channel, has a crucial role in calcium influx. TRPC5 has been reported to be activated by muscarinic receptor activation and extracellular pH change and inhibited by the protein ... View more