publication . Other literature type . Article . 2010

Structural Basis for the Growth Factor Activity of Human Adenosine Deaminase ADA2

Anton V. Zavialov; Xiaodi Yu; Dorothe Spillmann; Grégoire Lauvau; Andrey V. Zavialov;
  • Published: 09 Feb 2010
  • Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)
Abstract
Two distinct adenosine deaminases, ADA1 and ADA2, are found in humans. ADA1 has an important role in lymphocyte function and inherited mutations in ADA1 result in severe combined immunodeficiency. The recently isolated ADA2 belongs to the novel family of adenosine deaminase growth factors (ADGFs), which play an important role in tissue development. The crystal structures of ADA2 and ADA2 bound to a transition state analogue presented here reveal the structural basis of the catalytic/signaling activity of ADGF/ADA2 proteins. In addition to the catalytic domain, the structures discovered two ADGF/ADA2-specific domains of novel folds that mediate the protein dimeri...
Subjects
free text keywords: Protein Structure and Folding, Cell Biology, Biochemistry, Molecular Biology, Peptide sequence, Adenosine, medicine.drug, medicine, Transcription factor, Biology, Signal peptide, Signal transduction, Protein Dimerization, Glycosylation, chemistry.chemical_compound, chemistry, Adenosine deaminase, biology.protein
Abstract
Two distinct adenosine deaminases, ADA1 and ADA2, are found in humans. ADA1 has an important role in lymphocyte function and inherited mutations in ADA1 result in severe combined immunodeficiency. The recently isolated ADA2 belongs to the novel family of adenosine deaminase growth factors (ADGFs), which play an important role in tissue development. The crystal structures of ADA2 and ADA2 bound to a transition state analogue presented here reveal the structural basis of the catalytic/signaling activity of ADGF/ADA2 proteins. In addition to the catalytic domain, the structures discovered two ADGF/ADA2-specific domains of novel folds that mediate the protein dimeri...
Subjects
free text keywords: Protein Structure and Folding, Cell Biology, Biochemistry, Molecular Biology, Peptide sequence, Adenosine, medicine.drug, medicine, Transcription factor, Biology, Signal peptide, Signal transduction, Protein Dimerization, Glycosylation, chemistry.chemical_compound, chemistry, Adenosine deaminase, biology.protein
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publication . Other literature type . Article . 2010

Structural Basis for the Growth Factor Activity of Human Adenosine Deaminase ADA2

Anton V. Zavialov; Xiaodi Yu; Dorothe Spillmann; Grégoire Lauvau; Andrey V. Zavialov;