publication . Article . 2018

Glucose-6-pphosphate dehydrogenase deficiency allelic variants and their prevalence in malaria patients in Eritrea

Yohannes Ghebremedhin Tseghereda; Joseph Nyanga Murega; Andrew Nyerere Kimang'a; Tadesse Mehari Hagos; Gebrekidan Hadgu Yishak;
Open Access English
  • Published: 01 Sep 2018 Journal: The Pan African Medical Journal, volume 31 (eissn: 1937-8688, Copyright policy)
  • Publisher: The African Field Epidemiology Network
Abstract
Introduction Glucose 6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy with a relatively high frequency in malaria-endemic regions. In Eritrea, there is scanty knowledge of G6PD deficiency. The aim of the study was to characterize and determine the prevalence of four common G6PD allelic variants. Methods Three hundred and fourteen dried blood spot samples from unrelated microscopically diagnosed malaria patient Eritrean ethnic groups living in five zobas (regions) of Eritrea were analysed by PCR-RFLP method to identify the G6PD B, G6PD A (A376G), G6PD A-(G202A), and G6PD Mediterranean (C563T) variants. To confirm the RFLP results, sample...
Subjects
Medical Subject Headings: parasitic diseaseshemic and lymphatic diseasescongenital, hereditary, and neonatal diseases and abnormalitiesnutritional and metabolic diseases
free text keywords: Research, G6PD deficiency, PCR-RFLP, Eritrea, zoba, ethnic groups, malaria, Biology, Allele, medicine.disease, medicine, Dehydrogenase deficiency, Immunology
45 references, page 1 of 3

WHO_10 facts on malaria 2016.

Barat, LM. Four malaria success stories: how malaria burden was successfully reduced in Brazil, Eritrea, Vietnam and India. Am J Trop Med Hyg.. 2006; 74 (1): 12-6 [OpenAIRE] [PubMed]

Berhane, A, Mihreteab, S, Ahmed, H, Zehaie, A, Abdulmumini, U, Chanda, E. Gains attained in malaria control coverage within settings earmarked for pre-elimination: malaria indicator and prevalence surveys 2012, Eritrea. Malar J.. 2015; 14: 467 [OpenAIRE] [PubMed]

Sintasath, DM, Ghebremeskel, T, Lynch, M, Kleinau, E, Bretas, G, Shililu, J, Brantly, E, Graves, PM, Beier, JC. Malaria prevalence and associated risk factors in Eritrea. Am J Trop Med Hyg.. 2005; 72 (6): 682-7 [PubMed]

Berhane, A, Russom, M, Bahta, I, Hagos, F, Ghirmai, M. Rapid diagnostic tests failing to detect Plasmodium falciparum infections in Eritrea: an investigation of reported false negative RDT results. Malar J.. 2017; 16 (1): 105 [OpenAIRE] [PubMed]

Eritrean population 2018.

Shililu, J. Malaria vector studies in Eritrea. 2001

Kumar, P, Yadav, U, Rai, V. Prevalence of glucose-6-phosphate dehydrogenase deficiency in India: an updated meta-analysis. Egyptian J Med Hum Genet.. 2016; 17 (3): 295-302

Cappellini, MD, Fiorelli, G. Glucose-6-phosphate dehydrogenase deficiency. Lancet.. 2008; 371 (9606): 64-74 [PubMed]

Nkhoma, ET, Poole, C, Vannappagarib, V, Hall, SA, Beutlerd, E. The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis. Blood Cells Mol Disord.. 2009; 42 (3): 267-277

Ouattara, AM, Bisseye, C, Bazie, BVJTE, Diarra, B, Compaore, TR, Djigma, F, Pietra, V, Moret, R, Simpore, J. Glucose-6-phosphate dehydrogenase deficiency is associated with asymptomatic malaria in a rural community in Burkina Faso. Asian Pac J Trop Biomed.. 2014; 4 (8): 655-658 [OpenAIRE] [PubMed]

Luzzatto, L, Nannelli, C, Notaro, R. Glucose-6-phosphate dehydrogenase deficiency. Hematolol Oncol clin North Am.. 2016; 30 (2): 373-393

Howes, RE, Piel, FB, Patil, AP, Nyangiri, OA, Gething, PW, Dewi, M, Hogg, MM, Battle, KE, Padilla, CD, Baird, J, Kevin, null, Hay Simon, I. G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map. PLoS Med.. 2012; 9 (11): e1001339 [OpenAIRE] [PubMed]

Monteiro, WM, Val, FF, Siqueira, AM, Franca, GP, Sampaio, VS, Melo, GC. G6PD deficiency in Latin America: systematic review on prevalence and variants. Mem Inst Oswaldo Cruz.. 2014; 109 (5): 553-568 [OpenAIRE] [PubMed]

Mason, PJ, Bautista, JM, Gilsanz, F. G6PD deficiency: the genotype-phenotype association. Blood Rev.. 2007; 21 (5): 267-283 [PubMed]

45 references, page 1 of 3
Abstract
Introduction Glucose 6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy with a relatively high frequency in malaria-endemic regions. In Eritrea, there is scanty knowledge of G6PD deficiency. The aim of the study was to characterize and determine the prevalence of four common G6PD allelic variants. Methods Three hundred and fourteen dried blood spot samples from unrelated microscopically diagnosed malaria patient Eritrean ethnic groups living in five zobas (regions) of Eritrea were analysed by PCR-RFLP method to identify the G6PD B, G6PD A (A376G), G6PD A-(G202A), and G6PD Mediterranean (C563T) variants. To confirm the RFLP results, sample...
Subjects
Medical Subject Headings: parasitic diseaseshemic and lymphatic diseasescongenital, hereditary, and neonatal diseases and abnormalitiesnutritional and metabolic diseases
free text keywords: Research, G6PD deficiency, PCR-RFLP, Eritrea, zoba, ethnic groups, malaria, Biology, Allele, medicine.disease, medicine, Dehydrogenase deficiency, Immunology
45 references, page 1 of 3

WHO_10 facts on malaria 2016.

Barat, LM. Four malaria success stories: how malaria burden was successfully reduced in Brazil, Eritrea, Vietnam and India. Am J Trop Med Hyg.. 2006; 74 (1): 12-6 [OpenAIRE] [PubMed]

Berhane, A, Mihreteab, S, Ahmed, H, Zehaie, A, Abdulmumini, U, Chanda, E. Gains attained in malaria control coverage within settings earmarked for pre-elimination: malaria indicator and prevalence surveys 2012, Eritrea. Malar J.. 2015; 14: 467 [OpenAIRE] [PubMed]

Sintasath, DM, Ghebremeskel, T, Lynch, M, Kleinau, E, Bretas, G, Shililu, J, Brantly, E, Graves, PM, Beier, JC. Malaria prevalence and associated risk factors in Eritrea. Am J Trop Med Hyg.. 2005; 72 (6): 682-7 [PubMed]

Berhane, A, Russom, M, Bahta, I, Hagos, F, Ghirmai, M. Rapid diagnostic tests failing to detect Plasmodium falciparum infections in Eritrea: an investigation of reported false negative RDT results. Malar J.. 2017; 16 (1): 105 [OpenAIRE] [PubMed]

Eritrean population 2018.

Shililu, J. Malaria vector studies in Eritrea. 2001

Kumar, P, Yadav, U, Rai, V. Prevalence of glucose-6-phosphate dehydrogenase deficiency in India: an updated meta-analysis. Egyptian J Med Hum Genet.. 2016; 17 (3): 295-302

Cappellini, MD, Fiorelli, G. Glucose-6-phosphate dehydrogenase deficiency. Lancet.. 2008; 371 (9606): 64-74 [PubMed]

Nkhoma, ET, Poole, C, Vannappagarib, V, Hall, SA, Beutlerd, E. The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis. Blood Cells Mol Disord.. 2009; 42 (3): 267-277

Ouattara, AM, Bisseye, C, Bazie, BVJTE, Diarra, B, Compaore, TR, Djigma, F, Pietra, V, Moret, R, Simpore, J. Glucose-6-phosphate dehydrogenase deficiency is associated with asymptomatic malaria in a rural community in Burkina Faso. Asian Pac J Trop Biomed.. 2014; 4 (8): 655-658 [OpenAIRE] [PubMed]

Luzzatto, L, Nannelli, C, Notaro, R. Glucose-6-phosphate dehydrogenase deficiency. Hematolol Oncol clin North Am.. 2016; 30 (2): 373-393

Howes, RE, Piel, FB, Patil, AP, Nyangiri, OA, Gething, PW, Dewi, M, Hogg, MM, Battle, KE, Padilla, CD, Baird, J, Kevin, null, Hay Simon, I. G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map. PLoS Med.. 2012; 9 (11): e1001339 [OpenAIRE] [PubMed]

Monteiro, WM, Val, FF, Siqueira, AM, Franca, GP, Sampaio, VS, Melo, GC. G6PD deficiency in Latin America: systematic review on prevalence and variants. Mem Inst Oswaldo Cruz.. 2014; 109 (5): 553-568 [OpenAIRE] [PubMed]

Mason, PJ, Bautista, JM, Gilsanz, F. G6PD deficiency: the genotype-phenotype association. Blood Rev.. 2007; 21 (5): 267-283 [PubMed]

45 references, page 1 of 3
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2018

Glucose-6-pphosphate dehydrogenase deficiency allelic variants and their prevalence in malaria patients in Eritrea

Yohannes Ghebremedhin Tseghereda; Joseph Nyanga Murega; Andrew Nyerere Kimang'a; Tadesse Mehari Hagos; Gebrekidan Hadgu Yishak;