publication . Article . Other literature type . 1997

Selective block of N-methyl-d-aspartic acid (NMDA)-evoked whole-cell currents in mouse cultured spinal neurones by CGP 40116

D'Hooge, R; Raes, A; Van Bogaert, P P; Geelhand, M; De Deyn, P P;
Open Access
  • Published: 09 Jan 1997 Journal: British Journal of Pharmacology, volume 120, pages 211-214 (issn: 0007-1188, eissn: 1476-5381, Copyright policy)
  • Publisher: Wiley
Abstract
CGP 40116 is the active (R)-enantiomer of the most potent N-methyl-d-aspartic acid (NMDA) receptor antagonist presently available: 2-amino-4-methyl-5-phosphono-3-pentenoic acid (CGP 37849). In this study, we describe the effect of CGP 40116 on whole-cell currents induced by excitatory amino acids in cultured mouse spinal cord cells by use of the whole-cell patch-clamp technique. We found that application of CGP 40116 in the nm range, concentration-dependently inhibited whole-cell current evoked by 20 μm NMDA in mouse cultured spinal neurones (IC50±s.e.mean 48±8 nm CGP 40116). The compound appeared to be highly selective for the NMDA current. At concentrations as...
Subjects
Medical Subject Headings: sense organsnervous system
free text keywords: Pharmacology, NMDA receptor, N-Methyl-D-aspartic acid, chemistry.chemical_compound, chemistry, Kainate receptor, CGP-37849, AMPA receptor, Biochemistry, Receptor antagonist, medicine.drug_class, medicine, Kainic acid, 2-Amino-5-phosphonovalerate, Papers
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publication . Article . Other literature type . 1997

Selective block of N-methyl-d-aspartic acid (NMDA)-evoked whole-cell currents in mouse cultured spinal neurones by CGP 40116

D'Hooge, R; Raes, A; Van Bogaert, P P; Geelhand, M; De Deyn, P P;