publication . Article . Other literature type . 1984

Evidence that cyclic nucleotides are not mediators of fever in rabbits.

Dascombe, M. J.;
Open Access
  • Published: 01 Apr 1984 Journal: British Journal of Pharmacology, volume 81, pages 583-588 (issn: 0007-1188, Copyright policy)
  • Publisher: Wiley
Abstract
Abstract The N6-2'-O-dibutyryl derivative of adenosine 3',5'-monophosphate (db cyclic AMP) and related compounds have been micro-injected into the preoptic/anterior hypothalamic nuclei (PO/AH) of the unanaesthetized, restrained rabbit and the effects on deep body temperature observed. Db cyclic AMP (100-400 micrograms) produced hypothermia of rapid onset in rabbits at an ambient temperature of 20-23 degrees C. Hypothermia was also produced by N2-2'-O-dibutyryl guanosine 3',5'-monophosphate (db cyclic GMP), but not by saline, sodium n-butyrate, adenosine 3',5'-monophosphate (cyclic AMP), guanosine 3',5'-monophosphate, adenosine 5'-mono-, di- or triphosphate. The ...
Subjects
free text keywords: Pharmacology, Cholera toxin, medicine.disease_cause, medicine, Hypothermia, medicine.symptom, Endocrinology, medicine.medical_specialty, Adenosine, medicine.drug, Cyclase, Dibutyryl Cyclic GMP, Bucladesine, Guanosine, chemistry.chemical_compound, chemistry, Biochemistry, Internal medicine, Adenylate kinase, Research Article
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publication . Article . Other literature type . 1984

Evidence that cyclic nucleotides are not mediators of fever in rabbits.

Dascombe, M. J.;