Epigenetic PTEN Silencing in Malignant Melanomas without PTEN Mutation

Other literature type English OPEN
Zhou, Xiao-Ping; Gimm, Oliver; Hampel, Heather; Niemann, Theodore; Walker, Michael J.; Eng, Charis;
  • Publisher: American Society for Investigative Pathology
  • Related identifiers: pmc: PMC1850161
  • Subject: Regular Articles

A tumor suppressor gene at 10q 23.3, designated PTEN, encoding a dual specificity phosphatase with lipid and protein phosphatase activity, has been shown to play an important role in the pathogenesis of a variety of human cancers. Germline mutations in PTEN cause Cowden... View more
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