Mutation profiling of tumor DNA from plasma and tumor tissue of colorectal cancer patients with a novel, high-sensitivity multiplexed mutation detection platform

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Kidess, Evelyn; Heirich, Kyra; Wiggin, Matthew; Vysotskaia, Valentina; Visser, Brendan C.; Marziali, Andre; Wiedenmann, Bertram; Norton, Jeffrey A.; Lee, Mark; Jeffrey, Stefanie S.; Poultsides, George A.;

BACKROUND Circulating tumor DNA (ctDNA) holds promise as a non-invasive means for tumor monitoring in solid malignancies. Assays with high sensitivity and multiplexed analysis of mutations are needed to enable broad application. METHODS We developed a new assay based on... View more
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