publication . Article . Other literature type . Doctoral thesis . 2007

Helicobacter pylori VacA Enhances Prostaglandin E2 Production through Induction of Cyclooxygenase 2 Expression via a p38 Mitogen-Activated Protein Kinase/Activating Transcription Factor 2 Cascade in AZ-521 Cells

Hisatsune, Junzo; Yamasaki, Eiki; Nakayama, Masaaki; Shirasaka, Daisuke; Kurazono, Hisao; Katagata, Yohtaro; Inoue, Hiroyasu; Han, Jiahuai; Sap, Jan; Yahiro, Kinnosuke; ...
Open Access
  • Published: 25 Jun 2007 Journal: Infection and Immunity, volume 75, pages 4,472-4,481 (issn: 0019-9567, eissn: 1098-5522, Copyright policy)
  • Publisher: American Society for Microbiology
Abstract
<jats:title>ABSTRACT</jats:title> <jats:p>Treatment of AZ-521 cells with <jats:italic>Helicobacter pylori</jats:italic> VacA increased cyclooxygenase 2 (COX-2) mRNA in a time- and dose-dependent manner. A p38 mitogen-activated protein kinase (MAPK) inhibitor, SB203580, blocked elevation of COX-2 mRNA levels, whereas PD98059, which blocks the Erk1/2 cascade, partially suppressed the increase. Consistent with involvement of p38 MAPK, VacA-induced accumulation of COX-2 mRNA was reduced in AZ-521 cells overexpressing a dominant-negative p38 MAPK (DN-p38). Phosphatidylinositol-specific phospholipase C, which inhibits VacA-induced p38 MAPK activation, blocked VacA-ind...
Subjects
free text keywords: Immunology, Microbiology, Parasitology, Infectious Diseases, Biology, Protein kinase A, MAPK/ERK pathway, Gene expression, Transcription (biology), Activating transcription factor, Reporter gene, Transcription factor, Molecular biology, Activating transcription factor 2, biology.protein, Host Response and Inflammation
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Europe PubMed Central
Other literature type . 2007
JAIRO
Doctoral thesis . 2008
Provider: JAIRO
http://dx.doi.org/10.1128/iai....
Other literature type . 2007
Provider: Datacite
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publication . Article . Other literature type . Doctoral thesis . 2007

Helicobacter pylori VacA Enhances Prostaglandin E2 Production through Induction of Cyclooxygenase 2 Expression via a p38 Mitogen-Activated Protein Kinase/Activating Transcription Factor 2 Cascade in AZ-521 Cells

Hisatsune, Junzo; Yamasaki, Eiki; Nakayama, Masaaki; Shirasaka, Daisuke; Kurazono, Hisao; Katagata, Yohtaro; Inoue, Hiroyasu; Han, Jiahuai; Sap, Jan; Yahiro, Kinnosuke; ...