publication . Article . 2016

Investigating intracranial tumour growth patterns with multiparametric MRI incorporating Gd‐DTPA and USPIO‐enhanced imaging

Boult, Jessica K.R.; Borri, Marco; Jury, Alexa; Popov, Sergey; Box, Gary; Perryman, Lara; Eccles, Suzanne A.; Jones, Chris; Robinson, Simon P.;
Open Access English
  • Published: 01 Sep 2016 Journal: Nmr in Biomedicine, volume 29, issue 11, pages 1,608-1,617 (issn: 0952-3480, eissn: 1099-1492, Copyright policy)
  • Publisher: John Wiley and Sons Inc.
Abstract
Abstract High grade and metastatic brain tumours exhibit considerable spatial variations in proliferation, angiogenesis, invasion, necrosis and oedema. Vascular heterogeneity arising from vascular co‐option in regions of invasive growth (in which the blood–brain barrier remains intact) and neoangiogenesis is a major challenge faced in the assessment of brain tumours by conventional MRI. A multiparametric MRI approach, incorporating native measurements and both Gd‐DTPA (Magnevist) and ultrasmall superparamagnetic iron oxide (P904)‐enhanced imaging, was used in combination with histogram and unsupervised cluster analysis using a k‐means algorithm to examine the sp...
Subjects
free text keywords: Research Article, MRI, breast metastases, gadolinium‐enhanced MRI, Research Articles, high grade glioma, USPIO
48 references, page 1 of 4

1 Ostrom QT, Gittleman H, Liao P, et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007–2011. Neuro Oncol. 2014;16:iv1–iv63.

2 Schouten LJ, Rutten J, Huveneers HA, Twijnstra A. Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma. Cancer. 2002;94:2698–2705.12173339 [PubMed]

3 Arshad F, Wang L, Sy C, Avraham S, Avraham HK. Blood–brain barrier integrity and breast cancer metastasis to the brain. Pathol Res Int. 2010;2011:920509

4 Giese A, Westphal M. Glioma invasion in the central nervous system. Neurosurgery. 1996;39:235–250. discussion 250–232 8832660 [PubMed]

5 Rees J. Advances in magnetic resonance imaging of brain tumours. Curr Opin Neurol. 2003;16:643–650.14624071 [PubMed]

6 O'Connor JP, Rose CJ, Waterton JC, Carano RA, Parker GJ, Jackson A. Imaging intratumor heterogeneity: role in therapy response, resistance, and clinical outcome. Clin Cancer Res. 2015;21:249–257.25421725 [OpenAIRE] [PubMed]

7 Walker‐Samuel S, Boult JK, McPhail LD, Box G, Eccles SA, Robinson SP. Non‐invasive in vivo imaging of vessel calibre in orthotopic prostate tumour xenografts. Int J Cancer. 2012;130:1284–1293.21469141 [PubMed]

8 Just N. Histogram analysis of the microvasculature of intracerebral human and murine glioma xenografts. Magn Reson Med. 2011;65:778–789.21337410 [PubMed]

9 Lemasson B, Valable S, Farion R, Krainik A, Remy C, Barbier EL. In vivo imaging of vessel diameter, size, and density: a comparative study between MRI and histology. Magn Reson Med. 2013;69:18–26.22431289 [OpenAIRE] [PubMed]

10 Munoz R, Man S, Shaked Y, et al. Highly efficacious nontoxic preclinical treatment for advanced metastatic breast cancer using combination oral UFT‐cyclophosphamide metronomic chemotherapy. Cancer Res. 2006;66:3386–3391.16585158 [PubMed]

11 Workman P, Aboagye E, Balkwill F, et al. Guidelines for the welfare and use of animals in cancer research. Br J Cancer. 2010;102:1555–1577.20502460 [OpenAIRE] [PubMed]

12 Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol. 2010;8:e1000412 20613859 [OpenAIRE] [PubMed]

13 Jamin Y, Boult JK, Li J, et al. Exploring the biomechanical properties of brain malignancies and their pathologic determinants in vivo with magnetic resonance elastography. Cancer Res. 2015;75:1216–1224.25672978 [OpenAIRE] [PubMed]

14 Walker‐Samuel S, Orton M, McPhail LD, et al. Bayesian estimation of changes in transverse relaxation rates. Magn Reson Med. 2010;64:914–921.20806382 [PubMed]

15 Walker‐Samuel S, Orton M, Boult JK, Robinson SP. Improving apparent diffusion coefficient estimates and elucidating tumor heterogeneity using Bayesian adaptive smoothing. Magn Reson Med. 2011;65:438–447.21264934 [PubMed]

48 references, page 1 of 4
Abstract
Abstract High grade and metastatic brain tumours exhibit considerable spatial variations in proliferation, angiogenesis, invasion, necrosis and oedema. Vascular heterogeneity arising from vascular co‐option in regions of invasive growth (in which the blood–brain barrier remains intact) and neoangiogenesis is a major challenge faced in the assessment of brain tumours by conventional MRI. A multiparametric MRI approach, incorporating native measurements and both Gd‐DTPA (Magnevist) and ultrasmall superparamagnetic iron oxide (P904)‐enhanced imaging, was used in combination with histogram and unsupervised cluster analysis using a k‐means algorithm to examine the sp...
Subjects
free text keywords: Research Article, MRI, breast metastases, gadolinium‐enhanced MRI, Research Articles, high grade glioma, USPIO
48 references, page 1 of 4

1 Ostrom QT, Gittleman H, Liao P, et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007–2011. Neuro Oncol. 2014;16:iv1–iv63.

2 Schouten LJ, Rutten J, Huveneers HA, Twijnstra A. Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma. Cancer. 2002;94:2698–2705.12173339 [PubMed]

3 Arshad F, Wang L, Sy C, Avraham S, Avraham HK. Blood–brain barrier integrity and breast cancer metastasis to the brain. Pathol Res Int. 2010;2011:920509

4 Giese A, Westphal M. Glioma invasion in the central nervous system. Neurosurgery. 1996;39:235–250. discussion 250–232 8832660 [PubMed]

5 Rees J. Advances in magnetic resonance imaging of brain tumours. Curr Opin Neurol. 2003;16:643–650.14624071 [PubMed]

6 O'Connor JP, Rose CJ, Waterton JC, Carano RA, Parker GJ, Jackson A. Imaging intratumor heterogeneity: role in therapy response, resistance, and clinical outcome. Clin Cancer Res. 2015;21:249–257.25421725 [OpenAIRE] [PubMed]

7 Walker‐Samuel S, Boult JK, McPhail LD, Box G, Eccles SA, Robinson SP. Non‐invasive in vivo imaging of vessel calibre in orthotopic prostate tumour xenografts. Int J Cancer. 2012;130:1284–1293.21469141 [PubMed]

8 Just N. Histogram analysis of the microvasculature of intracerebral human and murine glioma xenografts. Magn Reson Med. 2011;65:778–789.21337410 [PubMed]

9 Lemasson B, Valable S, Farion R, Krainik A, Remy C, Barbier EL. In vivo imaging of vessel diameter, size, and density: a comparative study between MRI and histology. Magn Reson Med. 2013;69:18–26.22431289 [OpenAIRE] [PubMed]

10 Munoz R, Man S, Shaked Y, et al. Highly efficacious nontoxic preclinical treatment for advanced metastatic breast cancer using combination oral UFT‐cyclophosphamide metronomic chemotherapy. Cancer Res. 2006;66:3386–3391.16585158 [PubMed]

11 Workman P, Aboagye E, Balkwill F, et al. Guidelines for the welfare and use of animals in cancer research. Br J Cancer. 2010;102:1555–1577.20502460 [OpenAIRE] [PubMed]

12 Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol. 2010;8:e1000412 20613859 [OpenAIRE] [PubMed]

13 Jamin Y, Boult JK, Li J, et al. Exploring the biomechanical properties of brain malignancies and their pathologic determinants in vivo with magnetic resonance elastography. Cancer Res. 2015;75:1216–1224.25672978 [OpenAIRE] [PubMed]

14 Walker‐Samuel S, Orton M, McPhail LD, et al. Bayesian estimation of changes in transverse relaxation rates. Magn Reson Med. 2010;64:914–921.20806382 [PubMed]

15 Walker‐Samuel S, Orton M, Boult JK, Robinson SP. Improving apparent diffusion coefficient estimates and elucidating tumor heterogeneity using Bayesian adaptive smoothing. Magn Reson Med. 2011;65:438–447.21264934 [PubMed]

48 references, page 1 of 4
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue